Reproduction, mutation, natural selection and struggle for existence are all things that all living things must experience.
Because the first meaning of life is survival.
In order to survive, there must be struggle. There is a competition for resources between organisms, and there is also a competition between organisms and the natural environment. In this process, some microorganisms can live in peace with human beings and even benefit each other, while others will make people sick, usually bacteria, fungi, viruses, mycoplasma and chlamydia. These are clinical pathogenic microorganisms.
Natural selection takes a long time, but in recent years, environmental pollution and drug abuse have accelerated the evolution of pathogenic microorganisms, and the emergence of drug-resistant bacteria and superbugs has seriously threatened human health.
There are also some microorganisms that originally did not intersect with humans and originally only existed in nature. Some people eat wild animals out of curiosity, thus bringing the viruses carried by these animals to human society. For example, the SARS virus at the beginning of this century is an example. This new virus poses a great challenge to public health, and personal greed has brought great disasters to people all over the world.
When health was threatened, human beings invented antibiotics, viruses and antiviral drugs to deal with bacteria. But how to treat it, the first step is to find out the culprit, which is often difficult to do in clinic.
Traditional blood routine or imaging indexes of organs and tissues can judge the possibility of infection, but they cannot be used as the basis for diagnosis. For example, a blood routine can only tell you whether there is a bacterial or viral infection, but it can't tell you what bacteria or virus it is. Further examination is needed to confirm the diagnosis and prescribe the right medicine.
Laboratory tests, such as antigen detection, nucleic acid detection, metabolite detection and toxin detection, are important means to identify infection, guide treatment and judge prognosis.
In order to overcome the shortcomings of traditional methods, the application of ngs in the detection of pathogenic microorganisms has great advantages, such as:
Of course, NGS also has some shortcomings:
Even with its shortcomings, ngs has more obvious technical advantages. NGS is fast, accurate and high-resolution in identifying difficult microorganisms and rare bacteria that are difficult to cultivate or even isolate, especially in the outbreak and epidemic monitoring of new pathogenic microorganisms. NGS has become the gold standard for virus identification and plays an important role in epidemiological classification.
Novel coronavirus (20 19, coronavirus pneumonia-19) is raging all over the world. At present, there is no vaccine and no specific medicine. People have no choice but to wear masks, pay attention to personal hygiene and increase social distance. In the face of the raging epidemic, we should remind mankind once again to put down the arrogance of the universe, because microorganisms are well-deserved kings of the earth, and they are on this planet.
We can't and shouldn't try to destroy all microorganisms. Our relationship is not only confrontation, but also cooperation, but when our health is threatened, we should also dare to fight.
Natural selection, survival of the fittest, cooperation and struggle between human beings and microorganisms will go on forever.