Which drugs can fluconazole capsules not be taken with in clinic?

It mainly includes candidiasis, aspergillosis, cryptococcosis, zygomycosis and Penicillium Manneffei. Fluconazole capsules belong to imidazole antifungal drugs. Broad antifungal spectrum. Oral or intravenous injection of this product can cause fungal infections in humans and various animals, such as Candida infection (including systemic candidiasis in humans and animals with normal or impaired immune function), Cryptococcus neoformans infection (including intracranial infection), Malassezia furfur, Microsporum, Trichophyton, Trichophyton epidermidis, Blastomycosis (including intracranial infection), Histoplasma capsulatum and Staphylococci. The antibacterial activity of fluconazole capsule in vitro is obviously lower than that of ketoconazole, but its in vivo activity is obviously higher than that in vitro. Then there is drug interaction: in one experiment, fluconazole prolonged the prothrombin time of healthy male volunteers taking warfarin. Although the change range is small (12%), it is suggested that patients who use fluconazole and coumarins at the same time should strictly monitor the prothrombin time. Fluconazole can prolong the serum half-life of sulfonylurea drugs (chloroiodophor, glibenclamide, pyrithione hexaurea, tolbutamide) in healthy volunteers. Diabetic patients can take fluconazole and oral sulfonylureas at the same time, but be alert to the possibility of hypoglycemia. In one experiment, when healthy volunteers taking fluconazole took multiple doses of hydrochlorothiazide at the same time, their plasma concentration of fluconazole increased by 40%. Doctors should pay attention to this, but this change is not enough for patients taking fluconazole and diuretics to adjust the dose of fluconazole at the same time. When fluconazole and phenytoin sodium are taken at the same time, the plasma concentration of phenytoin sodium increases, which has clinical significance. If it is necessary to take two drugs at the same time, the blood concentration of phenytoin sodium should be monitored to adjust its dose and make its blood concentration at the therapeutic level. The pharmacokinetic interaction between oral contraceptives and multi-dose fluconazole showed that fluconazole, 50mg once,/kloc-0 once a day, did not cause any related changes in hormone levels; The area under the curve (AUC) of ethinylestradiol and levonorgestrel increased by 40% and 24% respectively when fluconazole was 0.2g 1 time and 1 time. Therefore, the effect of taking oral contraceptives at the same time will not be affected when taking fluconazole at the above dose. Fluconazole capsules were taken together with food, cimetidine or antacid or immediately after whole body irradiation of bone marrow transplantation, and its absorption did not change significantly. Taking fluconazole and rifampicin at the same time can reduce the AUC of the former by 25% and shorten the half-life by 20%. Therefore, patients taking fluconazole and rifampicin at the same time should consider increasing the dose of fluconazole. In a pharmacokinetic study, fluconazole (0.2g once a day 1 time) slowly increased the concentration of cyclosporine in renal transplant patients. However, in another study, fluconazole (0. 1g once a day, 1g once a day) did not affect the cyclosporine concentration of bone marrow transplant patients. It is suggested that the blood concentration of cyclosporine should be monitored in patients taking fluconazole at the same time. In the placebo-controlled study, continuous administration of fluconazole for 0.2 g 0.2g 65438±04 days reduced the average plasma clearance rate of theophylline by 65438 08%. Patients who take large doses of theophylline or are at risk of other theophylline poisoning should pay attention to the symptoms of theophylline poisoning when taking fluconazole at the same time. If there are symptoms of theophylline poisoning, the dosage regimen should be adjusted accordingly. Doctors should also pay attention to other drug interactions that have not been studied but may exist.