The increase of serum IgE is the most powerful hint of allergic diseases. Allergens enter the body to induce specific IgE, which combines with mast cells and eosinophils to make the body enter a state of specific sensitization to allergens. When the allergen comes into contact again, it will combine with the IgE receptor on the cell membrane to cause a series of biochemical reactions, and then release various bioactive mediators related to allergic reactions and inflammation, such as histamine.
Allergy is an immune disease, which is an imbalance of human immune function. In clinical investigation, patients with allergic constitution often find that multiple allergic diseases can be seen in the same patient. Compared with normal people, patients with allergic constitution have significantly higher serum IgE, more mast cells and more IgE receptors on cell membrane. Clinical medicine has proved that helper T cells and their cytokines play an important role in regulating the composition of IgE. According to the secretion of cytokines, helper cells are divided into two subgroups: TH 1 and TH2. Cytokines secreted by TH2 cells play an important role in antibody formation and allergic reaction. TH 1 and TH2 are regulated by cytokines. Under healthy conditions, TH 1 and TH2 are simultaneously balanced and regulated by helper T cells. When helper T cells lack regulatory ability or come into contact with some foreign proteins or small molecules (such as dust mites, pollen or seafood, etc.). ), TH2 is over-activated, which leads to the excessive secretion of TH2 cell hormones, leading to the increase of IgE and serum IgE concentration. In order to reduce IgE antibody, it is necessary to supplement the compound antiallergic probiotic strains that reduce serum IgE antibody.
Reduce IgE
Studies have confirmed that Lactobacillus salivarius, Lactobacillus Grignard, Lactobacillus yoelii, Lactobacillus lactobacillus paracasei and Lactobacillus Roy all have significant antiallergic functions, among which Lactobacillus salivarius is the most studied strain among antiallergic lactic acid bacteria, and Lactobacillus salivarius is concentrated in Kangminyuan probiotics, and a physiologically acceptable probiotic composition with enhanced antiallergic ability is adopted. By promoting the secretion of interleukin-12(IL- 12) and interferon γ, allergic symptoms can be effectively improved, Th 1 immune response can be regulated, immunoglobulin IgE can be inhibited, and the allergic phenomenon of Th2 immune response can be improved. Anti-allergic probiotic strains bind to receptors on intestinal wall dendritic cells, activate the translation proteins in cells to move to the nucleus, and release a large number of cytokines, which is a link of innate immunity. Therefore, diabetic substances such as peptidoglycan, lipopolysaccharide and polysaccharide can indeed activate the development of T cells through the innate immune system.
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Allergic genetic factor
Allergy will be passed on from parents to children, and the genetic probability that both parents are allergic is 5-20%; The genetic probability of one parent being allergic accounts for 20-50%; The genetic probability of allergies in both parents is as high as 80%. Coupled with the deterioration of the living environment, the change of the food chain, all kinds of fast food are flooding the dining table, and food additives are widely used, so that all kinds of allergic diseases have multiplied several times in the last decade and become a social epidemic, and the number of patients is increasing exponentially every year.
Allergic environmental factors
The increase of allergic diseases is considered to be closely related to environmental changes, especially changes in living environment and diet. Probiotics in human intestine can stimulate the immune system, but if the content of antibiotics or steroids in daily life is too high, it will lead to the decrease of probiotics in intestine, so it can not effectively stimulate the production of helper T cells 1(Th 1), and the production of these helper T cells 1 is closely related to the occurrence of allergic diseases related to helper T cells 2(Th2). Therefore, if we can use anti-allergic probiotics to stimulate the immune system, stimulate Th 1 immune response that can regulate allergic immune response, and balance Th2 immune response caused by allergy, we can achieve the effect of improving allergic constitution.