Colorectal cancer is a common malignant tumor. Who is more likely to get colorectal cancer?

Colorectal cancer, colon cancer and rectal cancer are collectively referred to as colorectal cancer, which refers to malignant lesions that occur under the influence of various carcinogenic factors such as the environment or heredity of colorectal mucosa. The mortality rate of colorectal cancer is high. What are the causes of colorectal cancer complicated with malignant tumor and common digestive tract malignant tumor? The etiology of colorectal cancer and its malignant tumor has not been clearly related to the following factors: 1, environmental factors. Studies have proved that the incidence of colorectal cancer is positively related to the high fat consumption of food, and it can also be related to the lack of trace elements and the change of living habits. The genetic factor "familial colorectal cancer" has been reported at home and abroad. The number of blood relatives of colorectal cancer patients who died of this disease was significantly higher than that of ordinary people. In some colorectal adenomas with multiple familial adenomas, the family prevalence of autosomal dominant genetic diseases is 50%. All patients aged 65,438+00 have colorectal cancer. Recently, some scholars have studied the relationship between tumor suppressor genes and colorectal cancer, and found that the susceptibility and pathogenesis of colorectal cancer are related to genetic factors. According to the research of autopsy data in various places, it is found that the incidence of colorectal adenoma is quite similar to that of colorectal cancer. According to statistics, the incidence of colorectal cancer in patients with 1 adenoma is five times higher than that in patients without adenoma, and patients with multiple adenomas are 1 times higher than those with single adenoma. It is reported that the prevalence of colorectal cancer is positively correlated with schistosomiasis endemic areas. It is believed that due to schistosomiasis, some inflammatory changes in the intestine will become cancer. Chronic inflammation of the intestine can also become cancerous. About 3%~5% of ulcerative colitis will become cancerous. Doctors believe that the incidence of colorectal cancer is related to insufficient stomach cold, dietary restriction and invasion of exogenous pathogens. The early symptoms of colorectal cancer are asymptomatic. In fact, patients with symptoms have appeared in clinic, and their local lesions are often obvious and serious, even the early symptoms of late colorectal cancer. The shape of feces turns from coarse to fine, the feces are black or dark red, the feces become thinner, and the number of mucus stools increases, but the feces are repeatedly discharged. The causes of hemorrhoids are more obvious, and the causes of anemia and weight loss are obvious. Can colorectal cancer be inherited? With the deepening of epidemiological research, more and more evidence shows that colorectal cancer is related to heredity. It has been found that some people and families have so-called cancer families or family aggregation of colorectal cancer. With the progress of molecular biology research of tumor cells, it has been gradually proved that some family members have the tendency of canceration-the phenomenon of loss of heterozygosity of tumor suppressor genes, which makes the cells of certain specific groups more prone to canceration under the multiple effects of carcinogens and carcinogens, although great progress has been made in the study of genetic genes at present. More studies show that multifactorial diseases caused by multi-etiology, multi-stage and multi-mutation of colorectal cancer are only caused by a single internal cause (genetic defects, etc.). ) or a single external factor (carcinogenic environment, etc.). ), but a variety of factors alternate and interact. It should be said that before the final formation of cancer, genetic factors, carcinogenic factors and cancer-promoting factors have multiple effects. In a word, the familial aggregation tendency of colorectal cancer can be related to both genetic factors and environmental factors, and both genetic factors and environmental factors can satisfactorily explain the relationship between familial aggregation tendency of colorectal cancer and regular intestinal diseases of colorectal cancer patients in third-degree relatives. At present, although the root cause of cancer is not fully understood, many scholars have realized that colorectal cancer cells are not contagious, but colorectal cancer can also be infected with infectious diseases. Some healthy mice were kept with a group of mice with cancer for a long time, but no healthy mice were found to be infected with cancer. Humans are also like tumors. No mutual infection was found among cancer patients in the same ward. Doctors and nurses are in close contact with patients in the hospital. Nurses have never heard of being infected with cancer. In fact, someone has done a survey: the incidence of cancer among medical staff and researchers engaged in cancer prevention and treatment is also higher than that of people in the same area. Couples who have lived for a long time have been living with cancer and have not infected each other. In the problem of cancer cell inoculation, the living cells of the same animal in the laboratory have been inoculated with the cancer samples of the same animal or athymic nude mice. Some people have not been directly vaccinated with the same animal cancer samples. Living cancer cells failed to obtain the same cancer specimen, because the human body itself has the function of rejecting foreign tissues, and tumor cells in the human body can be successfully inoculated. Therefore, it is unnecessary for surgeons or nurses in the operating room to hurt their skin carelessly during tumor surgery, and to be afraid of cancer cell inoculation infection or direct contact infection when they are in close contact with patients. It is also beneficial to take some disinfection and isolation measures from the perspective of hygiene to prevent the occurrence of infectious diseases. It is pointed out that some carcinogenic viruses are contagious, causing hepatitis B virus, gastric cancer caused by Helicobacter pylori, nasopharyngeal carcinoma caused by EB virus, and gastritis, gastric ulcer and hepatitis B for a long time. Therefore, strict precautions should be taken against hepatitis B virus and Helicobacter pylori.