Ornithine aspartate for injection
Ornithine aspartate for injection.
Wuhan ruiqi pharmaceutical co., ltd
Efficacy: It is mainly used to treat hyperammonemia caused by acute and chronic liver diseases such as liver cirrhosis, fatty liver, hepatitis, etc., especially suitable for relieving symptoms of central nervous system and rescuing hepatic coma caused by liver diseases. The treatment of hepatic coma can refer to the following scheme: 20g is given twice within 6 hours before the first day, and each intravenous injection is 10g. When using this product, fully dissolve it with appropriate amount of water for injection, and then add 0.9% sodium chloride injection or 5% 10% glucose.
Pharmacological action This product can provide a substrate for the synthesis of urea and glutamine. Glutamine is the detoxification product of ammonia, and it is also the storage and transportation form of ammonia. Under physiological and pathological conditions, the synthesis of urea and glutamine will be influenced by ornithine, aspartic acid and other dicarboxylic compounds. Ornithine almost involves the whole process of urea cycle activation and ammonia detoxification. In this process, arginine is formed, and urea is split to form ornithine aspartic acid, which participates in the synthesis of nucleic acid in liver cells and is beneficial to repair damaged liver cells. In addition, due to the indirect promotion of aspartic acid to the circulating metabolism of tricarboxylic acid in liver cells, the energy production in liver cells was promoted and the function of damaged liver cells was restored.
Adverse reactions (> 40k/L) caused by high-dose intravenous injection may include mild to moderate digestive tract reactions, such as nausea, vomiting or abdominal distension. Reduce the dosage or slow down the dripping speed (
Contraindications are allergic to amino acids and severe renal failure (serum creatinine >; 3mg/ 100ml) patients are prohibited.
Product specification 2.5g
Usage and Dosage Acute hepatitis 5- 10g intravenous drip every day, chronic hepatitis or cirrhosis 10-20g intravenous drip every day.
(If the condition is serious, it can be increased appropriately, but according to clinical experience, it is advisable not to exceed 40g every day. )
Storage method: avoid light, seal and store in a dry place.
Precautions when using this product in large quantities, pay attention to monitoring the urea index in blood and urine. Ornithine aspartate granules
Properties of ornithine aspartate This product is white or white-like particles with sweet and sour taste.
Function: It can be used to treat hyperammonemia caused by acute and chronic liver diseases, such as liver cirrhosis, fatty liver and hepatitis, especially for treating early disturbance of consciousness or nervous system complications.
Pharmacology and Toxicology This product can provide substrates for the synthesis of urea and glutamine. Glutamine is the detoxification product of ammonia, and it is also the storage and transportation form of ammonia. Under physiological and pathological conditions, the synthesis of urea and glutamine is influenced by ornithine, aspartic acid and other dicarboxylic acids. Ornithine almost involves the whole process of urea cycle activation and ammonia detoxification. Arginine is formed in this process, and then urea is split to form ornithine. Aspartic acid participates in the synthesis of nucleic acid in hepatocytes, which is beneficial to repair damaged hepatocytes. In addition, due to the indirect promotion of aspartic acid to the circulating metabolism of tricarboxylic acid in liver cells, the energy production in liver cells was promoted and the function of damaged liver cells was restored.
Pharmacokinetics According to the literature, 65,438+00 healthy subjects on an empty stomach took a single dose of 5g ornithine aspartate (the interval of blood concentration determination is the same as that of intravenous drip), and the concentration of ornithine reached a peak 30-60 minutes after taking the drug, which was 5 times higher than the baseline value, and then dropped to the baseline level within 7 hours. The AUC of ornithine is 65,438+065,438+043 μ mol h, similar to intravenous drip, and its bioavailability is about 82%. Oral ornithine aspartate is almost completely decomposed into ornithine and aspartic acid in the upper digestive tract, and its main metabolites are excreted with urine.
It is mainly used for treating hyperammonemia caused by acute and chronic liver diseases such as liver cirrhosis, fatty liver and hepatitis, and is especially suitable for the treatment of early disturbance of consciousness or nervous system complications.
Usage and dosage: Unless otherwise specified, 1-3 times a day, 3g each time. Dissolve the contents of each package in sufficient solution (such as water, tea and juice) and take it after meals. If necessary, the dosage can be increased without danger, and it can also be used alternately with ornithine aspartate for injection every other week.
Adverse reactions This product has no obvious adverse reactions after oral administration. A few patients may have nausea, vomiting or abdominal distension, which will disappear automatically after stopping taking medicine.
Allergic to amino acids and severe renal failure (serum creatinine >; 3mg/ 100ml) patients are prohibited.
Precautions 1. When using this product in large quantities, pay attention to monitoring the urea index in blood and urine. Please keep it out of the reach of children.
The safety of medication for pregnant and lactating women has not been determined. No reproductive toxicity was found in animal experiments.
Please follow the doctor's advice when using drugs for children.
There is no data showing that elderly patients need to adjust their doses.
Lack of research data on drug interactions.
There are no reports of oral overdose of this product.
Specification 3g, 1g
Store in a dark place, sealed and kept in a dry place.
packaging bag
The validity period is tentatively set at 18 months. The name of the drug is ornithine aspartate.
Usage and Dosage Acute hepatitis, 65438+ intravenous drip 0-2 times a day. Chronic hepatitis or liver cirrhosis, 2-4 times a day, intravenous drip. (If the condition is serious, it can be increased appropriately, but according to clinical experience, it is advisable not to exceed 20 cigarettes a day. ) in the early stage of hepatic coma and the first day of hepatic coma, depending on the severity of the disease, no more than 20 intravenous drops can be given. (Please refer to the following treatment plan: take 8 drugs 6 hours before the first day, and then give them 3 times in 6 hours, with 4 intravenous drops each time. (Note: Yabosi M injection can be added to any common injection-such as 0.9% normal saline, 5%, 10% glucose water, etc. No adverse physical and chemical reactions have been found so far. However, due to venous tolerance, it is best not to add more than 6 tablets to 500 ml injection. )
Pharmacological action Because ornithine aspartate can directly participate in the metabolism of liver cells, it can activate two key enzymes of liver detoxification function towel, which is helpful to remove free radicals harmful to human body, enhance the detoxification function of liver, rapidly reduce excessive blood ammonia, and promote the repair and regeneration of liver cells themselves, thus effectively improving liver function and restoring the energy balance of the body.
Indications: Elevated blood ammonia and hepatic encephalopathy caused by acute and chronic liver diseases (such as hepatitis, cirrhosis, fatty liver and post-hepatitis syndrome).
Adverse reactions Because the two amino acids contained in this product are all amino acids that constitute food, this product has no carcinogenic, teratogenic and mutagenic effects. High-dose intravenous injection (> 40 g/l) will cause mild to moderate gastrointestinal reactions. When the dosage is reduced or the dropping speed is slowed down (
Preparations, injections and granules
Precautions for patients with severe renal failure are prohibited. (When the serum creatine salt concentration exceeds 3 mg/100 ml, it can be regarded as renal failure. ) When using this product in large quantities, pay attention to monitoring the urea index in blood and urine.