Ganoderma lucidum can increase superoxide dismutase, scavenge free radicals in vivo, reduce the content of malondialdehyde (MDA) in vivo, improve the fluidity and sealing degree of cell membrane, and protect bioactive substances such as cell membrane, organelles, nucleic acids and enzymes from being damaged by free radicals. The function of improving superoxide dismutase is mainly manifested in:
1. Improving the activity of cell superoxide dismutase (SOD) Ganoderma lucidum can improve the function of SOD in vivo, and its effect is related to the dose of Ganoderma lucidum. Li Rui, Han Qun, etc. When the dosage of Ganoderma lucidum was 62.5mg/kg, the SOD activity increased by 65,438 04% compared with the control group, and when the dosage of Ganoderma lucidum was 500mg/kg, the SOD activity increased by 32.7% compared with the control group.
2. Inhibit the generation of superoxide anion free radicals.
3. Inhibition of lipid peroxidation can lead to the destruction of cell membrane structure, reduce or lose the physiological activity of cell membrane, and reduce the active absorption capacity of cell membrane. Lipoprotein, the product of lipid peroxidation, will accumulate on the inner wall and epidermis of blood vessels, causing blood circulation disorder and senile plaque, reducing the level of lipid peroxidation in the body, which is of great significance for improving the health of the body, delaying aging and improving the function of the nervous system.
(2) Anti-thrombosis and improvement of erythrocyte deformability
Ganoderma lucidum can improve the deformability of red blood cells and reduce platelet aggregation.
(3) Ganoderma lucidum can improve the ability of cells to synthesize DNA, RNA and protein.
Ganoderma lucidum can improve the activity of DNA polymerase and the ability of liver, bone marrow and red blood cells to synthesize DNA, RNA and protein.
(4) improve the body's immunity
Ganoderma lucidum has a very good effect on improving immune function. Ganoderma lucidum can promote the proliferation of lymphocytes, improve the phagocytosis and lethality of macrophages, NK cells and T cells, significantly inhibit the sensitization of ovalbumin and tetanus toxoid to intravenous mice, and promote the reaction of normal mice to sheep red blood cells (SRBC) and plaque-forming cells (PFC). Ganoderma lucidum can promote the proliferation of mouse spleen lymphocytes induced by concanavalin A and lymphocyte transformation stimulated by homologous antigen in vitro.
(5) The protective and detoxicating effects of Ganoderma lucidum.
Ganoderma lucidum has a good effect on protecting the liver from chemicals and viruses. Ganoderma lucidum can prevent and treat hepatitis caused by hepatitis virus mainly by improving the immune function of the body; The resistance of Ganoderma lucidum to toxic chemicals is mainly achieved by improving the detoxification ability of the liver.
(6) Ganoderma lucidum can improve the body's hypoxia tolerance, improve the blood oxygen supply capacity, improve the oxygen difference between muscles and veins, and reduce the oxygen consumption of the body at rest.
(7) Reduce blood viscosity, increase myocardial contractility, increase coronary blood flow and cardiac output, and improve heart rhythm.
(8) Anti-tumor Ganoderma lucidum can prevent tumor occurrence and inhibit tumor growth. It has a good inhibitory effect on transplanted tumors in animals, but it has a poor inhibitory effect on primary tumors.
(nine) to resist the harm of radiation and toxic chemicals to the body.
The experimental results show that Ganoderma lucidum extract can resist radiation and toxic chemicals (such as carbon tetrachloride, cyclophosphamide, carbon disulfide, benzene, etc.). ) to the body. Mice were injected with cyclophosphamide first, then ganoderma lucidum extract for 20 hours, and their physiological indexes were measured by anatomy. The results showed that the ability of synthesizing DNA, RNA and protein in liver, bone marrow and serum of mice was close to that of normal mice. The number of white blood cells, platelets and red blood cells is similar to that of normal mice. Mice were given Ganoderma lucidum extract orally, and then irradiated with lethal dose of Co60. After 1 week, all the control groups died, and the mortality rate of Ganoderma lucidum group was 20%. Ganoderma lucidum prevents the increase of micronucleus rate of bone marrow cells, and its effect is similar to that of radiation protection agent L- cysteamine.
(10) has sedative and analgesic effects
Ganoderma lucidum has obvious analgesic and sedative effects. Intraperitoneal injection of Ganoderma lucidum tincture solution (equivalent to 1g/ml)20g/kg can significantly reduce spontaneous activity of mice and prolong their sleep time. It can significantly enhance the action of pentobarbital sodium, prolong its action time and reduce its half effective dose, and its minimum dose is reduced from 35mg/kg to 25.36mg/kg.
(eleven) other medicinal functions of Ganoderma lucidum
In addition to the above pharmacological effects, it is reported that Ganoderma lucidum has the functions of improving vitality and resilience, relieving asthma, relieving cough, eliminating phlegm and treating chronic bronchitis, as well as lowering blood sugar, blood lipid and blood pressure, so I won't go into details here.
Toxicity of (12) Ganoderma lucidum
Animal acute and subacute toxicity tests show that several kinds of Ganoderma lucidum which have been developed and applied at present have extremely low toxicity, and all oral deaths are caused by overfeeding, and Ganoderma lucidum has no side effects.
Ganoderma lucidum, also known as Ganoderma lucidum and mushroom, is mainly used for medicine and contains polysaccharides, amino acids, triterpenoids and alkaloids. Pharmacological research shows that Ganoderma lucidum has the functions of protecting liver, detoxicating, strengthening heart, calming, invigorating stomach, diminishing inflammation and relieving pain. At the same time, it is helpful to improve human immunity and enhance disease resistance. Eating more ganoderma lucidum can prolong life.