Ginger: Simple bone metastasis can be treated with arnoldine and bisphosphonate.
Ginger: Arnold is a new anti-tumor drug. In most specialized hospitals and large general hospitals, drugs can be purchased with a doctor's prescription. At present, both national medical insurance and Beijing medical insurance are included in the scope of reimbursement.
Jiang: If the disease recurs or worsens after tamoxifen treatment, it belongs to clinical drug resistance. Of course, a new generation of endocrine drugs or chemotherapy should also be replaced as soon as possible. In order to avoid the possible tamoxifen resistance in theory, early adjuvant therapy should be given after operation, and new aromatase inhibitors or inactivators should be replaced in advance when the condition has not deteriorated. Because, international clinical research has proved that in the clinical research of early postoperative recurrence prevention, after taking tamoxifen for two years, it is better to switch to anoxin for three years than to use tamoxifen continuously for five years.
Jiang: The purpose of treatment of bone metastasis should be to control symptoms and prevent bone-related events such as fractures. It is quite difficult to completely eliminate bone metastasis, but patients who fail to treat with anastrozole can consider using another new endocrine drug-Arnold new therapy. At the same time, bisphosphonates should be used reasonably.
Ginger: You can consider using a new aromatase inhibitor or deactivator, such as Arnold. But the reason for dressing change is not because of the intima thickness, because if it is a postmenopausal woman, the intima thickness is 9 mm, which is not a contraindication to use tamoxifen. The purpose of dressing change is to achieve better endocrine therapy effect. Of course, the 48-year-old patient should check the hormone level to determine whether it is really amenorrhea. If the hormone level does not reach the postmenopausal level, she can continue to use tamoxifen and regularly monitor indicators including endometrial thickness.
Ginger: Because tamoxifen is a weak estrogen drug, it may stimulate intimal thickening. According to the above situation, we should consider stopping tamoxifen and switching to aromatase inhibitors with better curative effect and lower adverse reactions.
Sun Qiang: At present, our pathological report on HER-2 is positive for immunohistochemistry. The overexpression of HER-2 can not be completely confirmed, and immunofluorescence should be used to detect it. If it is positive, it will suggest that HER-2 is overexpressed. Herceptin can reduce the recurrence if it is clear that HER-2 is overexpressed, but it is not necessary.
Falloten and tamoxifen are similar drugs. If tamoxifen has obvious side effects, you can consider switching to Fallot.
It's good for netizens to be healthy: my mother had bilateral radical mastectomy last year. After the operation, she only had chemotherapy, not radiotherapy.
ECT scan found lumbar bone metastasis, menopause, pr++, er++, cerbb 2++,
Sun Qiang: If your mother is a postmenopausal, consider using aromatase blockers, such as fluoxetine and anoxin.
For premenopausal patients, drug-induced oophorectomy should be used. For example, bone scanning must be reviewed once every two to three months to judge the curative effect. If the lesion develops,
It shows that endocrine therapy is ineffective and chemotherapy can be considered. If there is only one bone metastasis, surgical resection of the lesion can be considered.