Monosialic acid tetrahexose ganglioside
Pharmacological action Ganglioside is a sphingolipid containing sialic acid, which exists in mammalian cell membrane and is especially abundant in nervous system. Ganglioside is a component of nerve cell membrane, which plays an essential role in the process of neurogenesis, growth and differentiation, and is also very important for nerve repair after injury. It has the functions of promoting nerve regeneration, promoting axon growth and synapse formation, and restoring innervation. Improve nerve conduction and promote the recovery of EEG activity and other electrophysiological indexes; Protect cell membrane and promote the recovery of cell membrane enzyme activity.
GM 1 is one of the most important gangliosides and plays an important role in the treatment of central nervous system diseases. GM 1 not only has the above-mentioned * * effect of ganglioside, but also can maintain the ion balance inside and outside the cell by maintaining the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase on the central nerve cell membrane, reduce the edema of nerve cells and prevent the accumulation of intracellular Ca2+. GM 1 can resist the neurotoxicity of excitatory amino acids and reduce the damage of free radicals to nerve cells. Therefore, GM 1 has the function of promoting nerve remodeling (neuroplasticity), that is, by promoting the improvement of various morphology, biochemistry, histochemistry, neurophysiology and parameters, the nerve repair is finally accelerated and the original nerve function is restored to the greatest extent.
GM 1 can promote the recovery of nerve function and nerve remodeling after central nervous system injury caused by various reasons. Experiments show that GM 1 can promote the recovery of nerve cells in vascular brain injury and traumatic brain injury and protect cells.
Indications Central nervous system diseases include brain and spinal cord injuries, cerebrovascular accidents and Parkinson's disease.
Adverse reactions A small number of patients have skin rash-like reactions after using this product, so it should be suggested to stop using it.
Usage and dosage: 20-40 mg daily, intramuscular injection or slow intravenous drip once or more according to the doctor's advice. Acute stage of lesion (ten thousand acute injuries): daily 100mg, intravenous drip; After 2-3 weeks, the maintenance dose was changed to 20-40 mg per day, which generally lasted for 6 weeks.
For Parkinson's disease, the first dose is 500- 1000 mg, intravenous drip; 200mg daily from the second day, subcutaneous, intramuscular injection or intravenous drip, usually used until 18 weeks.
Precautions have been confirmed to be allergic to this product; Hereditary abnormal glucose and lipid metabolism (familial amaurosis, retinopathy and other ganglioside accumulation diseases) is prohibited. Specification injection: 20mg:2ml, 100mg:5ml.