Does non-invasive dna have chromosome display? There will be a chromosome display. NIPT- invasive DNA means non-invasive gene detection, non-invasive prenatal detection and non-invasive fetal chromosome aneuploidy detection. The most widely used technical name in the world is NIPT, which is defined by the Committee of American College of Obstetrics and Gynecology.
Limited by the level of technological development, at present, domestic non-invasive DNA mainly screens three common chromosomal diseases, namely, chromosomal abnormality T2 1 (Down syndrome), chromosomal abnormality T 18 (Edwards syndrome) and chromosomal abnormality T 13 (Pato syndrome).
According to the Technical Specification for Prenatal Screening and Diagnosis of Quantitative Gene Sequencing in Qualcomm (Trial) issued by the National Health and Family Planning Commission (hereinafter referred to as? Norm? ), non-invasive DNA is a way of prenatal screening and diagnosis using gene sequencing technology. It is only necessary to collect more than 5ml of maternal peripheral venous blood and extract fetal free DNA fragments contained in maternal peripheral plasma. Through the new generation of Qualcomm DNA sequencing and biological information analysis, we can know the genetic information of the fetus and detect the risk rate of fetal chromosome aneuploidy.
The general cost of non-invasive DNA prenatal testing is about 2800-3500 yuan.
According to local charging standards, the price of non-invasive DNA ranges from 1000 yuan to 3500 yuan. The National Health and Family Planning Commission announced the list of the first batch of 109 prenatal diagnosis technical service institutions. For example, on the government website of the Guangdong Provincial Health Planning Commission, it can be found that there are 32 institutions in Guangdong Province that can do non-invasive DNA prenatal testing. In the case of adjusting the charging standard, the determination of the cost of non-invasive DNA also depends on the specific charging situation of the actual investigation project of the service organization. Chen Min, director of the Center for Prenatal Diagnosis and Fetal Medicine of the Third Affiliated Hospital of Guangzhou Medical University, said that a non-invasive DNA prenatal examination costs more than 3,000 yuan, while the traditional Down's screening only costs about 500 yuan to 600 yuan.
Special reminder, don't be greedy and cheap. Pregnant women should choose a formal institution with qualifications and related technical equipment to do non-invasive DNA to ensure the accuracy of screening, which is more likely to give birth to a healthy baby.
According to the guidelines issued by the National Health Planning Commission, the accuracy of non-invasive DNA is over 90%, including 2 1- trisomy syndrome, 18- trisomy syndrome and 13- trisomy syndrome. The detection rates of these three common chromosomal diseases are not less than 99%, 97% and 90% respectively. The compound false positive rate should be less than or equal to 0.5%; The composite positive predictive value is greater than or equal to 50%.
Is noninvasive DNA accurate in practical application? In view of the limitations of current medical testing technology and the individual differences of pregnant women, the regulations also give suggestions: the results of non-invasive DNA prenatal testing show that low risk is not the final diagnosis, and there is still the possibility of missed detection. Even pregnant women with high-risk screening results should not terminate their pregnancy hastily, and follow-up interventional prenatal diagnosis can be carried out. Interventional prenatal diagnosis includes amniocentesis, umbilical cord blood puncture and chorionic villus biopsy. , mainly used to prevent Down's baby from being born.
To do non-invasive DNA prenatal testing, it is necessary to collect the peripheral venous blood of pregnant women first. Is it necessary to draw blood on an empty stomach for noninvasive DNA? There is no need for fasting, and normal diet will not affect the test results. Han Jin, Department of Prenatal Diagnosis, Guangzhou Women and Children Medical Center, introduced that this technology is to detect a small amount of fetal DNA in pregnant women's blood through medical means, which is different from the serological markers of pregnant women found in similar screening in the past.
In addition, if blood collection also involves routine blood tests such as liver function, blood sugar and blood lipid, it is suggested to discuss with doctors whether it is necessary to carry out non-invasive DNA prenatal testing alone or simultaneously.
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