If the subject has a history of disease examination, such as a certain degree of liver injury in the past, the researcher needs to judge that the liver injury is CS (abnormality has clinical significance, and the clinical significance is related to the history of liver injury) when judging the corresponding indicators without affecting the enrollment.
Then another situation is that the abnormality caused by drugs or clinical trials has clinical significance, and there are two results here.
If the original medical history continues to deteriorate under the influence of drugs, it is necessary to record or judge it on the basis of the original CS, or the researchers should know it clearly (it is recommended to record it and forget it after a long time, after all, I don't know when it will come for verification). Remarks mainly need to judge the correlation with drugs.
New adverse events, including signs and indicators and related images, must be recorded as CS.