Intravenous medical equipment

Completely normal 1. Urine alkalizer will reduce the solubility of this product in urine, leading to crystalline urine and renal toxicity. 2. When quinolones are used in combination with theophylline, the liver elimination of theophylline is obviously reduced, the blood elimination half-life (t 1/2) is prolonged, and the blood concentration is increased, which may lead to theophylline poisoning symptoms, such as nausea, vomiting, tremor, anxiety, excitement, convulsion and palpitation. Although this product has little effect on the metabolism of theophylline, it is still necessary to determine the plasma concentration of theophylline and adjust the dose when combined. 3. The combination of this product and cyclosporine can increase the blood concentration of cyclosporine, so it is necessary to monitor the blood concentration of cyclosporine and adjust the dose. 4. Although the anticoagulant effect of warfarin is slightly enhanced when this product is used together with warfarin, the prothrombin time of patients should be closely monitored when it is used together. 5. Probenecid can reduce the secretion of this product from renal tubules by about 50%, and it can be poisoned by the increase of blood drug concentration when used together. 6. This product can interfere with caffeine metabolism, thus reducing caffeine elimination, prolonging the half-life of blood elimination (t 1/2β), and may cause central nervous system toxicity. Levofloxacin injection 7. Acid-making drugs and iron agents containing aluminum and magnesium can reduce the oral absorption of this product and should not be combined. 8. When this product is used with Fenbufen, a non-steroidal anti-inflammatory drug, it occasionally twitches, so it is not suitable to use it with Fenbufen. 9。 When this product is mixed with Xiangdan injection, precipitation and turbidity may occur, so it cannot be mixed in the same container. When they need to be used together, they must be separated by other liquids or washed with salt water. 10. The combination of this product and oral hypoglycemic drugs may cause blood sugar disorder, so the blood sugar concentration should be monitored during the medication. Once hypoglycemia occurs, this product should be stopped immediately and appropriate treatment should be given. Levofloxacin and Shuanghuanglian injection have serious adverse reactions. The National Adverse Drug Reaction Monitoring Center released the latest issue of information bulletin on adverse drug reactions, reminding medical institutions and medical staff of pharmaceutical production and operation enterprises to be alert to the serious adverse reactions of levofloxacin injection and Shuanghuanglian injection. According to reports, the serious adverse reactions/events of levofloxacin injection are mainly systemic damage, central and peripheral nervous system damage, skin and its accessories damage, respiratory system damage and gastrointestinal system damage, among which allergic reaction problems are typical, and the clinical manifestations are mainly anaphylactic shock, anaphylactoid reaction, dyspnea, erythema multiforme drug eruption and laryngeal edema. In the database of National Adverse Drug Reaction Monitoring Center, the analysis of serious case reports of levofloxacin injection shows that the product is used irrationally in clinic, and some irrational drug use problems have become the main factors causing serious adverse events. For example, the instructions of levofloxacin injection clearly indicate that patients below 18 are used in the database, and patients below 18 use the drug and cause serious adverse events. The National Adverse Drug Reaction Monitoring Center suggested that clinicians should use levofloxacin injection in strict accordance with the Guiding Principles for Clinical Application of Antibacterials and the drug instructions. Avoid incompatibility, and choose reasonable antibiotics when combined use is really necessary. Use with caution or under strict supervision in patients with renal insufficiency, elderly patients and patients with nervous system diseases. Medical staff should carefully observe the symptoms and signs of patients in the process of medication, and stop taking drugs immediately if any abnormality is found, and make a clear diagnosis as soon as possible and give symptomatic treatment in time. Shuanghuanglian injection notified at the same time is a traditional Chinese medicine preparation made from extracts of honeysuckle, scutellaria baicalensis and forsythia suspensa. It has the effects of clearing away heat and toxic materials, expelling wind and relieving exterior syndrome, and is often used to treat fever, cough and sore throat caused by exogenous wind and heat. 20011The National Center for Adverse Drug Reaction Monitoring reported the allergic reaction caused by Shuanghuanglian injection for the first time. After the announcement, serious adverse reactions/incidents of Shuanghuanglian injection were still reported. It is reported that the serious adverse reactions/events of Shuanghuanglian injection are mainly systemic damage and respiratory system damage. The irrational clinical use of this product, and some irrational drug use problems have caused serious adverse events. Irrational drug use is mainly manifested in the following aspects: contraindications, multiple drugs or drugs with contraindications are mixed in the same infusion set one after another, and there is no other liquid interval; Children overdose; Medication for allergic patients, etc. The National Adverse Drug Reaction Monitoring Center advises medical staff to fully understand the function and indications of Shuanghuanglian injection, strictly grasp its indications, weigh the advantages and disadvantages of patients' treatment and use drugs carefully. Clinically, besides intravenous infusion, try to choose relatively safe oral Shuanghuanglian preparation or intramuscular injection. Shuanghuanglian injection should be used with caution in medical institutions that do not have perfect first-aid drugs and equipment.