Request for Order No. 55 of the Ministry of Health

Article 1 According to the State Science and Technology Commission Decree No. 2 "Regulations on the Management of Laboratory Animals", in order to strengthen the scientific management of medical laboratory animals, to ensure the quality of laboratory animals, to meet the needs of scientific research, teaching, medical care, production, economic construction and development, the formulation of these rules.

Second Article The experimental animals referred to in these rules refers to the source of clear (genetic background and microbial control) for scientific research, teaching, medical care, production, verification and other scientific experiments on animals.

Article III of the management of medical laboratory animals should be consistent with the relevant national standardization laws and regulations and "Medical Laboratory Animal Management Implementation Rules" requirements, and the implementation of the laboratory animal certification system.

Article 4 The business of medical laboratory animals in the health system is guided by the Medical Laboratory Animal Management Committee of the Ministry of Health. The Ministry of Health to hire experts to form a laboratory animal expert advisory committee, as the Ministry of Health advisory body to assist the Ministry of Health in the macro aspects of medical laboratory animal science and technology development, prediction, assessment, technical policy, organization and coordination of advice, scientific research project demonstration and review of scientific research results.

Chapter II: Laboratory Animal Management Organization

Article 5: The Medical Laboratory Animal Management Committee of the Ministry of Health shall be composed of relevant personnel and experts hired by the Ministry of Health, and shall be responsible for the management of medical laboratory animals nationwide, the formulation of the relevant regulations and rules for the implementation of coordinating and supervising the work of medical laboratory animals in the provinces, autonomous regions and municipalities directly under the Central Government.

Article VI Provinces, autonomous regions and municipalities directly under the Central Health Department (Bureau) should be led to participate in the work of the medical laboratory animals in charge of hiring experts and managers to set up the province, (District) Medical Laboratory Animal Management Committee, under the leadership of the Department of Health (Bureau) is responsible for the province, (District) Medical Laboratory Animal Management, according to the unified standard is responsible for the issuance of the laboratory animal certificate of conformity in a professional by the Ministry of Health, the medical laboratory animal management committee and the guidance of the Ministry of Health. It is under the guidance and supervision of the Medical Laboratory Animal Management Committee, and at the same time accepts the unified leadership of the local science and technology commission on the macro level.

In accordance with the opinion of the State Science and Technology Commission, the regional medical laboratory animal management committees can join the inter-industry laboratory animal management committees organized by the regional science and technology commissions according to the situation. Beijing and Shanghai medical laboratory animal management committee is the pilot unit of the Ministry of Health, is also the first to be established in China. The two experimental animal management organizations should continue to do a good job.

Article VII Each unit shall set up a medical experimental animal management committee or group, whose personnel consists of scientific researchers, experimental animal management and its related administrative personnel, and whose leadership is in charge of scientific research by the leaders in charge of research work at the institution (institute) level. The management committee or group is responsible for the overall management of the unit related to experimental animals.

Chapter III Quality Inspection Standards for Medical Laboratory Animals

Article VIII Genetic Inspection Standards for Medical Laboratory Animals

Medical laboratory animals must be subjected to a scientific management system based on the requirements of genetic quality control in order to ensure the genetic quality standards of different animals (inbred lines, distantly inbred lines, closed herds and inbred lines).

Genetic quality standards of inbred strains of rats and mice

I. Management system

1. The source of introduction is clear, and should be accompanied by genealogical and biological characteristics information (such as the number of generations of inbreeding, the mode of mating, the genetic composition, and the biological characteristics), and should be in line with the internationally recognized standards of genetic profiling.

2. Population maintenance and production shall be carried out in accordance with the internationally recognized breeding system for inbred animals.

(1) The foundation group and the bloodline expansion group

shall be conducted by sibling mating. The maintenance of the foundation group must be carried out according to the inbred lineage preservation method, and should have genealogy and individual card records.

(2) Production group

Produced by random mating method (or traffic light method), it can be continuously bred for 3-5 generations, and its production group of breeding mice should be kept in relative parallel with the base group's blood relationship.

II. Genetic quality control

1. Selection of methods

(1) Allogeneic skin transplantation

Both rat and mouse allogeneic skin transplantation has been the classic method of identifying inbreeding lines, and it is listed as the preferred method due to its economy and authority.

(2) Biochemical electrophoresis method

This is 1 of the routine methods used in recent years to genetically monitor inbred animals using isozymes and protein polymorphisms. Because of its rapidity, accuracy, and sensitivity, it is unique compared with the skin grafting method in detecting sublineage animals, and it can be used as another important method for checking the genetic quality of inbred rats and mice.

2. Selection of loci

There are three main factors that contribute to the variation of genetic quality in inbred animals.

(1) genetic contamination;

(2) genetic drift;

(3) genetic mutation;

The genetic contamination is the greatest among these 3 aspects, while the other two, the frequency of change in a certain period of time is very low. Therefore, for locus selection, 8 differential loci located on 7 chromosomes were chosen as the first line loci to be examined based on the 10 commonly used existing inbred strains of mice. Some of these 8 loci will be heterozygous or variable if genetic contamination has occurred in any of the strains. Considering the selection of loci spread over as many chromosomes as possible, five more easily manipulated and less costly loci located on five chromosomes were then selected as the second line of loci to be examined. In rats, seven loci were selected for examination as the first line loci. In principle, if the examination of the first line locus reveals a problem, the examination of the second line locus will not be performed.

First line loci:

Hbb,Car-2, Gpd-1, Es-3, Trf,Gpi,Idh-1.

Second line loci:

Pgm -1, Es-10, Sep-1, Got-2.

3. Animal selection

At least four animal allogeneic skin grafts were performed for each strain of inbred rats and mice. Those with successful skin grafts were also required to send four animals (2 ♂, 2 ♀) from the core group for examination of biochemical loci. Those with failed skin grafts will not be considered for examination of biochemical loci. (See attached tables 1 and 2).

Article IX Microbiological Control Standards for Medical Laboratory Animals:

Level I: ordinary animals, i.e., pathogens that require exclusion of human and animal **** diseases;

Level II: clean animals, which require exclusion of pathogens that cause human and animal **** diseases as well as the major infectious diseases of animals;

Level III: Special Pathogens Free (SPF) animals, which require that some pathogens should be excluded in addition to achieving the level II standards. Some pathogens should also be excluded.

Level IV: Sterile animals, excluding all life forms that are not implanted.

I. Laboratory Animal Pathogenic Bacteria Detection Grade Standard (see Exhibit 5)

II. Laboratory Animal Virus Detection Grade Standard (see Exhibit 3 and 4)

III. Laboratory Animal Parasite Detection Grade Standard (see Exhibit 6)

Laboratory Animal Pathological Examination Standard:

Grade I: Common Animal

Appearance: Coat color Smooth, clean and close-fitting; active, no abnormal movement; head and face not swollen; back not dome up; no defects on limbs, tail and skin; no panting, no nasal discharge; anus clean.

Pathologic anatomy: liver, spleen, lymph nodes not enlarged; lungs, liver, spleen, kidneys without undue foci visible to the naked eye.

Grade 2: clean animals

have the indicators of a grade 1 common animal and no lesions of grade 2 microbial pathogens on microscopic examination.

Third level: animals free of specific pathogens

have the indicators of a first-grade common animal and the absence of lesions of microbial pathogens of second- and third-grade animals.

Grade IV: Sterile animals

In addition to having grade I indicators and containing no lesions of microbial pathogens of grade II and III animals; organs such as spleen and lymph nodes have the histologic structure of sterile animals.

Animals with genetic mutations, immunodeficiencies, etc. can be examined according to the provisions of the individual strain characteristics.

Chapter IV Medical Laboratory Animal Conditions and Facilities Inspection Standards

Article 10 of the standards for experimental animals and animal laboratory facilities

It is to ensure that the genetic characteristics of the experimental animals, microbiological control standards for the relative stability of the results of the experiments and the scientific level for the purpose.

Article XI should be the structure of the laboratory animal facilities:

I. Front area, including: isolation and quarantine room, storage, office, feed storage, maintenance room and corridor.

Second, the control area (feeding area), including: breeding room, population expansion room, breeding room, to be issued room, clean goods storage room, feed production room and clean corridors.

Third, the logistics area, including: scrubbing and disinfection room, waste storage, disposal room, dirt corridors and so on.

Article XII Requirements for Laboratory Animals and Animal Experiment Facilities

I. General Animals (Usual Animals)

1. Outer Environment Conditions

(1) The yard is neat, clean, and disinfected on a regular basis;

(2) There is a certain green area;

(3) There are special storage places for garbage, animal carcasses, and autopsy room, animal carcasses must be incinerated within 24 hours or disposed of according to relevant regulations;

(4) No non-experimental poultry or livestock shall be kept near the animal room.

2. Animal room building conditions:

(1) to meet certain building standards;

(2) small and medium-sized animal feeding room import and export shall not be directly to the outside, there should be a buffer room;

(3) there is an insect-proof screen door and window;

(4) the ceiling is smooth and clean, and can be disinfected;

(5) the ground is flat, and the floor and the walls can be scrubbed;

(6) the floor and the walls can be scrubbed;

(7) the floor is flat, and the floor and the walls can be scrubbed. walls can be washed;

(6) there should be running water and closed sewers (to prevent wild rats from scurrying in);

(7) there should be air-exchanging devices and equipment to prevent wild rats.

3. The environmental conditions of the rearing room:

(1) The annual temperature difference between the room temperature should be between 18 degrees and 29 degrees (for mice, guinea pigs, gophers, etc.

(2) The relative temperature should be 60%±20%;

(3) The ammonia content in the air should be less than 20 ppm:

(4) The noise level in the room is less than 60 db;

(5) There should be a ventilation device and anti-wild mouse equipment.

(5) The feeding room should be neat and clean, free of debris, dirt, insects, etc.

4. Cage and feeder conditions

(1) Cages that are easy to clean, disinfect and operate should be used;

(2) Feeders and drinking utensils need to be able to be disinfected, and should be made of materials that do not rust.

5. Management conditions

(1) system: there should be rules and regulations of the animal room, operation procedures, job responsibility system and work quota;

(2) work records: there are cage cards, diaries of the feeding room, and accounts of the animals;

(3) environmental records: temperature, humidity, etc. should be filled in truthfully;

(4) personnel hygiene: wear clean work clothes, wear work hats, hats, and other equipment;

(4) personnel hygiene: wear clean work clothes, wear work hats, and work hats, and work hats, and work hats, and work hats. work clothes, wearing a work cap, mask, gloves, work shoes, etc.

(5) bedding to be sterilized;

(6) to have a special bathing equipment for animal room staff.

6. Health and epidemic prevention facilities

(1) There should be washing and disinfecting equipment and system;

(2) There should be isolation and quarantine facilities as well as epidemic prevention measures.

Two, clean animals, in addition to meeting the requirements of ordinary animals, but also must meet the following requirements

1. Building conditions

(1) as far as possible to achieve the separation of cleanliness and pollutants;

(2) doors and windows to meet the requirements of sealing;

(3) buffer room;

(4) a shower room or changing room.

2. Environmental conditions of feeding room

(1) Relative humidity 60%±5%;

(2) Indoor noise below 55dB;

(3) Air exchange device: powerful ventilation, with medium-effect filtration, and air-conditioning device;

(4) Number of times of air exchange: 8 times/hour of full fresh air, and the room is at a positive pressure;

( (5) no insects indoors;

(6) indoor lighting: about 12 hours of light and dark or natural lighting that meets the requirements;

(7) the lower parts of the walls and floors of the rearing room are disinfected twice a week;

(8) the facilities for sewage disposal (including bedding, etc.) should be semi-closed and capable of disinfection to prevent cross-contamination.

3. Management conditions

(1) Work clothes, hats, feed, cages, feeding utensils, etc. should be disinfected;

(2) It is better for staff to shower and change clothes before entering the feeding area.

III. Requirements for special pathogen-free animals and sterile animal equipment. (See Exhibit 9)

IV. Laboratory Animal Laboratories

The minimum standards for laboratory animal laboratories shall be those of a laboratory animal rearing room of the appropriate laboratory animal class. Refer to the above regulations for specific requirements.

Article 13 Quality Control Standards for Laboratory Animal Feeds

1. The feeds used for experimental animals shall be formulated in accordance with the different physiological characteristics of various animals and the needs of different stages of growth and development, and the maximum safe limits of their nutritional components and harmful substances contained therein shall be formulated (see Annexes 7 and 8)

2. Scientifically designed formulas of various experimental animal feeds

1. A variety of experimental animal feed formula, should be based on the different needs of experimental animals energy scientific design.

2. Determine the feed formula shall not be changed arbitrarily, and strive to stabilize.

3. Feed shall not add antibacterial agents, anthelmintics, antiseptic mold and hormones and other drugs.

4. Non-standard feed shall not be used to feed experimental animals.

Three, raw material requirements and storage

1. Selected fresh, unadulterated, non-toxic, non-polluting, non-moldy, non-insect, rodent bites of various raw materials.

2. There should be a special feed storehouse

Feed storehouse should be kept dry, ventilated, no insects, no rodents, often keep clean and sanitary, all kinds of feed or raw materials should be classified and stacked neatly.

3. Vitamin raw materials should be stored in the light, low temperature and dry place.

4. Processed products and raw materials should be stored separately.

5. Feed warehouse is strictly prohibited to store miscellaneous goods and toxic drugs.

6. The feed storehouse must be established to strictly receive and issue, storage system and improve the management procedures.

Four, processing

Select high-quality raw materials in accordance with the ratio of feed formula, accurate weighing, fully mixed. Vegetable oil, vitamins and inorganic salts are mixed with a small amount of powder and then mixed with a large amount of powder after processing. The material made should be suitable hardness and palatability.

The finished blocks shall be put into non-toxic and clean feed barrels or clean paper bags, with the seals affixed or hung with labels indicating the type of feed, the date of production and the producer, and the finished blocks shall not be stored for more than two months.

Article XIV Requirements for Quarantine of Laboratory Animals

In order to prevent the occurrence of infectious diseases in the group of experimental animals, to avoid the newly introduced animals from causing harm to the original animals and the personnel concerned, and to improve the health of experimental animals, the following provisions are hereby stipulated:

I. Newly introduced animals must be isolated and quarantined, and can only be moved into the feeding area after determining that they are free from infectious diseases.

Second, not from the human and animal **** infectious disease infected areas of the introduction of animals.

Three, the death of animals with infectious diseases should be handled in a timely manner (pathological necropsy and laboratory examination), make a diagnosis, put forward the treatment of opinions, reported to the person in charge or the competent authorities (Laboratory Animal Management Committee at all levels).

Four, there are infectious diseases and undeserved non-infectious diseases of animals shall not be used for animal testing. In the event of infectious diseases, in principle, all destroyed; houses, utensils, cages and racks, bedding, clothing, shoes and hats, etc. must be thoroughly disinfected; animal rooms disinfected and closed for a certain period of time before being opened for use.

V. In case of virulent infectious disease epidemic in experimental animals, it should be reported to the Medical Laboratory Animal Management Committee immediately, and at the same time, strict isolation measures should be taken to prevent the spread of infectious diseases; if there is any delay or concealment of the report, the host unit shall be held liable, and revoke its certificate of conformity.

Sixth, the quarantine of wild animals, should be used by the unit in situ quarantine, after confirming that no human and animal **** disease and animal infectious diseases can be used.

Chapter V. Preservation, introduction, supply and application of experimental animals

Article 15 The preservation and introduction of seed referred to in these rules refers to the basic stock for the expansion of the production group to provide seed (the source of the stock is clear, including: the genetic background, the microbial control situation and relevant information).

Article XVI Breeding of Laboratory Animals

I. Breeding units must have facilities that meet the requirements of the level of laboratory animals, and be directly managed by senior and middle-level laboratory animal scientists and technologists, and regularly conduct quality testing.

Second, the seed preservation unit has the responsibility to provide seed to the production unit according to plan. Provided seed animals to have the head of the seed preservation unit issued by the person in charge of the labeled strain, genetic background, microbial control (animal grade and other information) and a copy of the certificate of conformity.

Third, the seed preservation unit has the right to introduce seed according to the introduction of the unit of guidance, the introduction of the unit is obliged to feedback on the production and use of seed.

Article XVII Introduction of Seeds of Laboratory Animals

I. The unit introducing seeds shall obtain the certificate of conformity for the production and supply of laboratory animals before introducing seeds.

II. Each unit of seed introduction shall regularly provide the management committee with relevant information on the production and breeding of the seeds introduced.

Three, in general, inbred production groups should be tested for genetic quality once a year.

Article XVIII of the supply of experimental animals

I, the production of experimental animals, the supply of experimental animals provided by the unit must ensure the quality of experimental animals, there should be a unit issued by the person in charge of the genetic background, microbial control of information and other relevant information and experimental animals and a copy of the Certificate of Conformity (indicating: the supply of the number and date of use of experimental animals and the subject) as a basis for the use of qualified experimental animals.

Two, the production and supply of laboratory animals shall not be supplied for scientific research projects have not yet obtained the certificate of conformity of the animals.

Three, the production and supply of experimental animals, the right to the unit has not yet obtained the certificate of conformity of the conditions of animal experiments, to stop the supply of experimental animals.

Four, the production of laboratory animals, supply units and the use of laboratory animals should abide by the supply and demand program contract signed by both sides (the contract should be signed in accordance with national contract law).

Article 19 Application of Laboratory Animals

I. The application of experimental animals should be based on different purposes, the selection of appropriate qualified experimental animals, and have the corresponding qualified animal experimental conditions. Declare the subject and assessment of scientific research results should be applied to qualified laboratory animals as a prerequisite; the application of unqualified laboratory animals made by the identification is invalid, the production of products shall not be put into use.

Second, the transportation of laboratory animals should be safe, reliable and meet the microbial control level requirements, shall not be mixed with different strains of animals, the transportation process should ensure that the health and safety of experimental animals.

Chapter VI Staff of Laboratory Animals

Article 20 The production and supply of laboratory animals must have an appropriate proportion of senior, intermediate and junior scientific and technological personnel. All types of personnel shall abide by the systems of laboratory animal feeding management.

Article 21 of the experimental animal breeding, production and supply units provided by the seed and experimental animals should have been recognized by the experimental animal scientific and technological personnel to sign the seal of responsibility.

Article 22 of the work of laboratory animals at all levels of personnel to implement the qualification recognition system, by the provincial and municipal medical laboratory animal management committee is responsible for the regular assessment, and regular training to improve the level of business, the results of the assessment as the basis for evaluation and promotion of technical titles.

Article 23 The staff engaged in experimental animals shall enjoy the necessary labor protection and welfare treatment to ensure their health.

Article 24 of the laboratory animal staff, should be regular physical health checks, found to be suffering from infectious diseases, especially human and animal **** sick, should be promptly transferred to work.

Chapter VII Rewards and Penalties

Article 25 of the Medical Laboratory Animal Management Committee at all levels of the long-term management of laboratory animal feeding, scientific research, loyal to their duties, hard work, and made significant achievements in the unit and individual, shall be given recognition, rewards, or honorary title.

Article 26 For violation of the rules and supply and application of unqualified laboratory animal production and supply and application units, by the Medical Laboratory Animal Management Committee, respectively, in different cases, to give a warning, a deadline for improvement, and ordered to close down, etc.; causing losses to pursue its administrative responsibility, civil liability; the circumstances are serious, constituting a crime, shall be held criminally liable.

Chapter VIII Supplementary Provisions

Article 27 These Rules shall be interpreted by the Medical Laboratory Animal Management Committee of the Ministry of Health.

Article 28 These Rules shall be implemented from June 1, 1989 onwards.

Table 1 Differential loci of 10 commonly used inbred mouse strains

------------------------------------------------------------------------------

Locus ( chromosome number)

Strain Hbb(7) Car-2(3) Gpd-1(4) Es-1(8) Es-3(11) Trf(9) Gpi-1(7) Idh-1(1)

---------------------------------- ------------------------------------

615 s a b b c b a a a

TA1 s b b a a b a a a

TA2 d a b b c b b b a

BALB/c d b b b b b a b a a

C57BL/6J s a a a a b b a

CBA/N d a b b c a b b

CBA/JOla d b b b c a b b

C3H/He d b b b c b b b b

DBA/2N d b b b c b a b

KK s a a b c b b a

Table 2 Differences in the four commonly used inbred rat strains Loci

------------------------------------------------------------

Locus

Es-3 Es-4 Es-6 ES-8 ES-9 ES-10

Strain

------------------------------------------------------------

F344/N a b a b a a a

LOU/cN a b b b b a a

SHR/Ola b a a b a a a

WKY/Ola d b b a a c b

Table 3 Criteria for Virus Detection Levels in Dentate Laboratory Animals

------ ---------- ---------- ---------- ---------- -------

｜ ｜ Animal species

Animal grade ｜ Virus ｜ ---------- -

｜ ｜ Rats｜Rats｜Guinea pigs｜Gophers

------ ---------- ---------- ---------- ---------- Lymphocytic Choriomegitis Virus(LCM)｜ 0 ｜ 0 ｜ 0

: ｜: ｜: ｜: ｜: ｜: Grade Passage｜Epidemic Hemorrhagic Fever Virus Epizootic Hemorrhagic Fever Virus(EHFV)｜ 0 ｜ 0 ｜ ｜ ｜ ｜

Sydney｜No｜Clear｜:. Eotromelia Virus (poxvirus of mice) ｜ 0 ｜ ｜ ｜

Sanitary｜Special｜Clean｜ ｜ ｜ ｜ ｜ ｜ ｜

Active｜Special｜Active｜--- ｜ ---------- ---------- ----------











Disease Disease｜Substances ｜Mouse Hepatitis Virus(MHV)｜ 0 ｜ ｜ ｜ ｜

(｜original｜-----｜-) ---------- ---------- ---------｜ -----｜｜---｜---

No｜Body ｜Simian Virus5(SV5)｜ ｜ 0 ｜ 0 ｜ 0

Bacteria｜Activity ｜ Sendai Virus ｜ 0 ｜ 0 ｜ 0 ｜ 0 ｜ 0

Activity｜Substances ｜ Pneumonia Virus of Mice(PVM)｜ 0 ｜ 0 ｜ 0 ｜ 0

Substances ｜ Reovirus Type 3(Reovirus Type 3(Reovirus Type 3)) Reovirus Type 3(Reo-3)｜ 0 ｜ 0 ｜ 0 ｜ 0

and ｜ ｜ Mouse Encephalomyelitis Virus ｜ 0 ｜ 0 ｜ 0 ｜ 0

Have ｜ ｜ Mouse Adenovirus(MAd)｜ 0 ｜ 0 ｜ 0 ｜ ｜

Knowing ｜ ｜KVirus (KV) ｜ 0 ｜ ｜ ｜

Bacteria ｜ ｜ Minute Virus of Mice (MVM) ｜ 0 ｜ ｜ ｜ ｜

Motion ｜ Polyoma Virus ｜ 0 ｜ ｜ ｜

Materials ｜ Toolan's Virus(H-1)Toolan's Virus(H-1)｜ 0 ｜ ｜ ｜

These viruses have been used for many years. Virus(H-1)｜ ｜ 0 ｜ ｜

)｜ ｜ Kilham's Rat Virus(KRV)｜ ｜ 0 ｜ ｜

｜ ｜ Rat Corona Virus(RCV)｜ ｜ 0 ｜ ｜ ｜

｜ Sialodacryoadenitis Virus(RV)｜ 0 ｜ ｜ ｜

｜ ｜ Sialodacryoadenitis Virus(SAV) ｜ 0 ｜ ｜ ｜

｜ ｜ Sialodacryoadenitis Virus(SAV) ｜ 0 ｜ ｜ ｜

Sialodacryoadenitis Virus (SDAV)｜ ｜ 0 ｜ ｜

｜ ｜ Epizootic Diarrhea of Infant Mice (EDIM)｜ 0 ｜ ｜ ｜

｜ ｜ Lactic Dehydrogenase Lactic Dehydrogenase Virus(LDH)｜ 0 ｜ ｜ ｜ ｜

｜ ｜ Mouse Cytomegalovirus(MCMV)｜ 0 ｜ ｜ ｜ ｜

｜---- ---｜------ ---------- ---------- ----｜---｜---｜- -----

｜No detectable viruses ｜ ｜ ｜ ｜ ｜ ｜

- ---------- ---------- ---------- ---------- ----------

Note: 0 requires none

Table 4 Criteria for virus detection levels in experimental rabbits, cats, dogs and monkeys

------ ---------- ---------- ---------- ---------- ---

｜ ｜ Animal species

Animal grade ｜ Virus ｜ ---- -------

｜ ｜ Rabbit｜ Cat｜ Dog｜ Monkey

- -------｜-- ---------- ---------- ------｜--｜- ---------

Four｜Three｜Two ｜ ｜ ｜ ｜ ｜ ｜ ｜ ｜

Class｜Class｜Class｜One Pass｜Rabies VirusRabies Virus ｜ ｜ ｜ 0 ｜

: ---------- ---------- --------｜- -｜--｜--｜--

｜Origin｜ ｜ Canine Parvovirus ｜ ｜ 0 ｜

｜Body｜ ｜ Simian Immunodeficiency D ｜ ｜ ｜ 0

｜Movement｜ ｜ Simian HIV ｜ ｜ 0

｜Monkey Immunodeficiency D ｜ ｜ ｜ 0

｜Activity ｜ ｜ Monkey Immunodeficiency D ｜ ｜ 0

｜Monkey Immunodeficiency D Immunodeficiency Virus ｜ ｜ ｜ ｜ ｜ ｜ 0

｜Activity｜----｜--- ---------- ---------- -----｜---｜--- ----

｜ ｜Monkey Foam Virus Simian Spumavirus ｜ ｜ ｜ ｜0

｜Monkey Virus 40 Simian Virus 40(SV 40)｜ ｜ ｜ ｜0