Pharmaceutical lyophilizer is a commonly used pharmaceutical equipment, its main components and systems are almost the same, different manufacturers have different configurations and ways to achieve the following for everyone to introduce the structure of the pharmaceutical lyophilizer:
1, box
Box for the AISI316L stainless steel square box, for the CIP device The standard box material is AISI316L, the optimized design makes the box not only easy to approach while minimizing dead corners.
2, door
Door is square, for SIP, CIP equipment standard door material is AISI316L. door chain is located on the left side of the door facing the door (according to the requirements of the right side can also be installed), the door can be opened 90 degrees. The inner surface of the door is mechanically polished to a mirror finish <0.4μmRa.
3. Product shelves
Shelves are made of AISI316L stainless steel, and the hollow structure of the shelves provides a circulating channel for the thermally conductive silicone oil.
4, cold trap
The cold trap and the box are separated, connected by an airflow channel.
5, the main valve
The box and the cold trap are connected by a 316L hydraulic mushroom valve
Two, the system composition of the pharmaceutical lyophilizer
Pharmaceutical lyophilizers consist of a box structure and the internal system, which is divided into a number of internal systems, including:
1, the hydraulic system: used for the small doors, partitions, and main valves, etc., hydraulic control and movement.
2, pneumatic system: pneumatic valves and so on.
3, product shelves of heat exchange system: the use of multiple circulating pumps, multiple plate and frame heat exchanger, heat exchange circuit with expansion box to compensate for the volume changes caused by temperature changes in different cycles.
4, refrigeration system: the refrigerant carrier flows through the evaporator (with liquid level), the evaporator refrigerant evaporation and heat absorption, and then the refrigerant vapor (evaporator steam) is pumped by the compressor (placed on the top of the evaporator), pressurized and warmed up to be discharged into the condenser, after the condensation of the water or wind cooling (with a certain level), the flow of refrigerant by the throttling device to control the flow of refrigerant evaporator. For a specific refrigerant, a specific pressure corresponds to the saturation temperature.
5. Vacuum system: it consists of one Roots pump and two dry pumps, with MKS manometer for vacuum control, with Pirani vacuum probe to monitor the pressure, and ordinary pressure transmitter to measure the rough vacuum and positive pressure.
6, ventilation system: to the box mixed with gas or freeze-drying after cracking the vacuum, but also play the role of frost to the cold trap ventilation.
7, CIP system: consists of CIP tanks, booster pumps, can be steam sterilized, through the pump to supply CIP water pressure, the lyophilizer for cleaning.
8, SIP system: sterilize the chamber and cold trap by 121 degrees pure steam.
9, drainage and water ring pump drying system: equipped with a water ring pump for evacuating and drying the cold trap after defrosting.
10, control system: through the PLC and HMI control and monitoring of the system.