Isotretinoin soft capsules are recommended for patients to use under the guidance of a doctor. In the course of medication, adverse reactions mainly occur in skin, teratogenicity, bones and neuromuscular aspects. Clinical side effects of isotretinoin mainly include the following six aspects:
1. Adverse reactions of skin and mucous membrane: cheilitis is the most common, with the incidence of 100%, which is characterized by dryness, chapping, peeling and bleeding of oral mucosa, similar to exfoliative dermatitis. Nearly 30% ~ 50% patients have symptoms such as nasal mucosa dryness, bleeding, dry skin and dry eyes, especially those who are allergic and dry.
2. Teratogenesis: Animal experiments have proved that oral isotretinoin can lead to developmental malformation, abortion and stillbirth. Administration at the early stage of fetal organ formation can lead to abnormal development of central nervous system and cardiovascular system; Administration in the third trimester of pregnancy can lead to fetal limb shortening and urinary system defects.
3. Effects on bones: Long-term application of isotretinoin can cause bone hypertrophy, calcification of tendons and ligaments, osteoporosis and epiphyseal atresia, thus affecting the growth and development of children and adolescents.
4. Influence on mental activity: It is reported that from the listing of 1982 isotretinoin to May 2000, 43 1 patient in the US Food and Drug Administration (FDA) had mental disorder after taking isotretinoin.
5. Neuromuscular Adverse Reactions: Foreign literatures reported that oral isotretinoin can cause headache, dizziness, drowsiness, myalgia and serum creatine kinase elevation (CK).
6. Abnormal laboratory examination: Oral isotretinoin can increase the levels of total cholesterol and triglyceride. Patients with hyperlipidemia, obesity and diabetes should try to avoid using isotretinoin.
Isotretinoin soft capsules are recommended for patients to use under the guidance of a doctor, and do not take drugs in excess or in one course of treatment. During the medication, pay attention to the occurrence of adverse reactions, especially the changes of skin reactions and blood sugar status. In case of serious adverse reactions, stop taking medicine immediately and seek medical attention.