The success rate of IVF is lower than that of the first and second generation IVF, which is about 15-30%. Only a few reproductive centers in China have this technology.
Natural cycle test-tube baby: Natural cycle test-tube baby is a new treatment method that everyone has begun to pay attention to in recent two years. The theoretical basis is that some patients have good ovarian reserves, and they can completely culture their reserved follicles into mature follicles through immature egg culture technology, and then conduct IVF. In this way, there is no need to use ovulation induction drugs, which avoids the repeated stimulation of drugs to the ovary, reduces the excessive stimulation to the ovary, and also reduces the treatment cost, because the drug cost accounts for 50% of the treatment cost of conventional IVF. If conventional IVF fails, it is usually necessary to rest the ovaries for 2-3 months before the next cycle of treatment. However, because there is no drug to stimulate the ovary in the natural cycle, the next month after failure can immediately enter the next cycle of treatment. This continuity of time is also more convenient for professional women and elderly women to shorten the treatment cycle.
At present, natural cycle has not been widely used, and there is no clear literature report on its success rate. However, it is generally believed that the success rate of natural cycle will be lower than that of ovulation induction cycle, and the excellent center can reach more than 30%.
Cryopreservation of oocytes: Cryopreservation technology of oocytes mainly uses special freezing technology to preserve eggs in liquid nitrogen and thaw them when necessary. This technique is suitable for patients with premature ovarian failure and loss of ovarian function, as well as some professional women who wish to delay childbearing. The hope of patients with premature ovarian failure or ovarian dysfunction mainly comes from eggs donated by other patients. Donated eggs can be frozen by egg freezing technology and taken out if necessary. In addition, some professional women want to delay childbearing, but they are worried that the quality of eggs will decline with the increase of age. They can adopt freezing technology and reuse it when they are young and old in oocyte cryopreservation.
The difficulty of this technique is that there is a lot of liquid in the follicle, which is easy to form ice crystals when frozen, destroying the tissue structure of the follicle, resulting in low success rate.
Frozen embryos: IVF technology can exceed the ovulation limit of human beings. Through drug ovulation, multiple eggs are produced in a menstrual cycle to form multiple embryos. However, multi-embryo transfer can not only improve the success rate, but also increase the occurrence of multiple births and the risk of maternal and infant death and complications. Therefore, all countries in the world generally have corresponding laws and regulations to limit the number of embryos implanted, and due to the progress of technology, the internationalization trend of single embryo transfer has begun to take shape. At present, the maximum number of embryos transferred in China is three. For patients with more than three embryos, extra high-quality embryos can be frozen in liquid nitrogen. If the embryo transfer is unsuccessful, frozen embryos can be transferred in the next treatment cycle. The success rate of frozen embryos is generally lower than that of fresh-cycle IVF 10%.
The world's first frozen embryo test-tube baby was born in Monassi. At present, almost all centers in China have mastered the technology of freezing embryos.