The most commonly used serological markers for detecting hepatitis B virus (HBV) infection are hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti -HBs), hepatitis B E antigen (HBeAg), hepatitis B E antibody (anti -HBe) and hepatitis B core antibody (anti -HBc) * *, so it is called "two halves of hepatitis B" and has three major functions. 2. To judge the infectivity of HBV infection; 3. As one of the bases for antiviral treatment and curative effect judgment of patients with chronic hepatitis B, the following are several common results and meanings.
Clinical significance of HBsAg anti -HBs HBeAg anti -HBe anti -HBc diagnosis results.
1+-+-+ "Big Three Yang" indicates HBV infection, active virus replication and strong infectivity.
2+-++ "Xiao Sanyang" indicates that there is HBV infection, but the virus replication is relatively static and the infectivity is relatively weak.
At the early stage of 3+-+ recovery, there was HBV infection, but the virus replication was relatively static and the infectivity was relatively weak.
At the late stage of 4-+++ recovery, it shows that HBV has been infected, but protective antibodies have been produced, which is not contagious and does not require hepatitis B vaccine injection.
The late stage of 5-+ recovery indicates that HBV has been infected.
The 6-+- complete recovery indicates that protective antibodies were produced after hepatitis B vaccine injection. If you haven't been injected with hepatitis B vaccine, it means that you have been infected with HBV, and now you have produced protective antibodies, which are not contagious and don't need to be injected with hepatitis B vaccine.
Description: "Two halves of hepatitis B" only reflects the infection and replication of HBV, but it cannot fully reflect the severity of the disease. For example, "Big Sanyang" is not necessarily serious, and "Small Sanyang" is not necessarily light. To judge the severity of hepatitis B, we should not only check the "two halves of hepatitis B", but also combine the results of liver function examination, liver fibrosis index, B-ultrasound and CT examination to accurately judge the current condition. In addition, in order to judge the replication status of HBV and the infectivity of patients more accurately, it is necessary to quantitatively detect HBV DNA.
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Five tests of hepatitis B
Is there hepatitis B virus in HBsAg?
Is surface antibody (anti-HBs) protective?
Is е antigen (HBeAg) virus replicable and contagious?
Is the replication of е antibody (anti-HBe) virus inhibited?
Has the core antibody (anti-HBc) ever been infected with hepatitis B virus?
Dasanyang
Surface antigen (HBsAg)+
е antigen (HBeAg)+
Core antibody (anti-HBc)+
This situation usually reflects that virus replication is active.
Xiaosanyang
Surface antigen (HBsAg)+
е antibody (anti-HBe)+
Core antibody (anti-HBc)+
Patients with small three-yang diseases should be tested for DNA. If it is positive, it reflects the active replication of the virus. If it is negative, it reflects that the virus is suppressed and the virus replication is inactive.
Clinical significance of serum markers of hepatitis B virus
Significance of HBsAg anti-HBs HBeAg anti-HBe anti-HBc
+-incubation period of acute HBV infection
+-+-Acute hepatitis occurs early and is highly contagious.
++++Acute or chronic infection is highly contagious.
++++Acute or chronic infection has low infectivity in the late stage.
+++HBV carriers with acute or chronic hepatitis B.
++ ++ HBsAg immune complex, a new subtype of infection.
++++① A subtype of HBsAg and a variant of anti -HBs (common)
② the process of transforming serum from HBsAg to anti -HBs (rare)
-+-+HBV infection, recovery period
-++①HBV infection has passed.
② Window period before anti -HBs appears.
-+-++HBV infection recovery period
-+-( 1) After vaccination
② Distant past infection
③ False positive