"Twelfth Five-Year" Biotechnology Development Plan
Ministry of Science and Technology
20 1 1 year 1 1 month
catalogue
I. Situation and demands 5
(A) Biotechnology is the commanding height of scientific and technological development in 2 1 century 5
(B) Biotechnology has become the strategic focus of competition among countries in the world.
(C) Biotechnology-led bio-industry will become a new growth point of economic development in 2 1 century 7
(D) Biotechnology will become a breakthrough in solving major human problems.
(e) Biotechnology will become the supporting point of biosafety 8
Second, the overall thinking and guiding principles of 9 pages
(A) the overall idea 9
(ii) Guiding principle 9
Three. Development goal 10
Four. Mission critical 1 1
(1) Strengthening prospective basic research 1 1
(2) Breaking through a number of core key technologies 13
(3) Develop a batch of major products and technical systems 16
(D) to strengthen the capacity building of biotechnology innovation 20
Verb (abbreviation of verb) safeguard 22
(A) to deepen system reform and innovation, improve the national coordination mechanism of biotechnology and industrial development 22 pages
(B) the establishment of multi-channel investment mechanism, increase financial, taxation, financial and other policy support.
(3) Encourage the combination of Industry-University-Research and promote the innovation capacity building of biotechnology enterprises.
(4) Improve the intellectual property system and establish a good incentive mechanism.
(E) innovative talent introduction and training mode, strengthen the construction of high-quality biotechnology talent team 23
(6) Expand international and regional cooperation and make full use of foreign superior technical talent resources.
Noun explanation: 25
Biotechnology is the main driving force for the development of international science and technology, and the bio-industry has become the focus of international competition, which has important strategic significance for solving the main problems faced by human beings such as population, health, food, energy and environment. The Outline of the National Medium and Long-term Scientific and Technological Development Plan (2006-2020) (hereinafter referred to as the Outline) regards biotechnology as one of the five strategic priorities of scientific and technological development. The Decision of the State Council on Accelerating the Cultivation and Development of Strategic Emerging Industries (hereinafter referred to as the Decision) adopted on September 20 10 also listed the biological industry as a strategic emerging industry. In order to implement the deployment of the Decision and the Outline, cooperate with the implementation of the Outline of the Twelfth Five-year Plan for National Economic and Social Development (20 1 1-20 15), and comprehensively promote the rapid development of biotechnology and industry in China, the Twelfth Five-year Plan for Biotechnology Development is formulated.
I. Situation and needs
(1) Biotechnology is the commanding height of scientific and technological development in 2 1 century.
Biotechnology is one of the fastest-growing high-tech fields in the world today. /kloc-since 0/0, the total number of papers in life science, biotechnology and related fields has accounted for more than 50% of the global natural science papers; In the past 10 years, life science and biotechnology accounted for more than 50% of the 10 scientific and technological progress selected by Science. Among the top 20 journals with SCI impact factors in 2008, 16 belongs to life science. The development of cutting-edge biotechnology such as genomics, protein omics and stem cells has made a qualitative leap in human understanding of the life world. Medical biotechnology will greatly improve human health and quality of life; Agricultural biotechnology will greatly improve the output and quality of agricultural products and reduce the cost of agricultural production; Industrial biotechnology will accelerate the development of "green manufacturing", greatly reduce pollutant emissions and reduce production costs; Developing biomass energy will effectively alleviate the pressure of energy shortage; Environmental biotechnology will play a great role in controlling environmental pollution and improving ecological environment; Biotechnology will also play an irreplaceable role in safeguarding national security and resisting the threat of bioterrorism. The related research of life science and biotechnology has occupied the leading position of scientific research.
(b) Biotechnology has become the strategic focus of competition among countries all over the world.
In order to seize the commanding heights of biotechnology, countries all over the world have formulated national strategic plans, introduced special policies and substantially increased capital investment. In 2009, the National Research Council of the United States released the report "New Biology in the 2 1 century: How to ensure that the United States leads the upcoming biological revolution", suggesting that countries take actions to accelerate the development of "new biology" and focus on strengthening the application of life sciences and biotechnology in food, energy, environment and health. In 20 10, the British biotechnology and bioscience research Council (BBSRC) issued a five-year plan for the development of biotechnology, namely, the era of bioscience: 2010/5 strategic plan, with frontier bioscience and technology as the first priority support area. Japan has raised the biotechnology industry to the height of national strategy, taking the strategy of "establishing the country through biotechnology industry" as Japan's new national goal, and developing the biotechnology industry through strong financial support. After the release of the long-term science and technology development plan "Vision 2025", the Ministry of Science and Technology of Korea also formulated the national plan "Biological Vision 20 16 (2006-20 16)" to guide and promote the development of biotechnology in Korea. In 2007, India issued a biotechnology development strategy, quadrupling its investment in biotechnology in five years. China's "Outline" regards biotechnology as one of the five strategic priorities of scientific and technological development. The Outline of the Twelfth Five-Year Plan for National Economic and Social Development proposes to cultivate and develop strategic emerging industries such as biology into the leading and pillar industries in China.
(3) Bio-industry led by biotechnology will become a new growth point of economic development in 2 1 century.
At present, biotechnology is entering the stage of large-scale industrialization, biomedicine and bio-agriculture are maturing, and bio-manufacturing, bio-energy and bio-environmental protection are rising rapidly. Global bio-industry sales double every five years, with an annual growth rate as high as 30%, which is 10 times that of the world economy. Bio-industry has become the fastest growing economic field. According to a research report of the United States in 2009, in 2008, the global income of medicine, biotechnology and life sciences industries reached 9 1 700 million US dollars, of which medicine accounted for 7.4.61%,reaching 684.2 billion US dollars, and biotechnology industry accounted for 2 1.27%, reaching1. According to Ernst & Young; The annual report of biotechnology industry released by Young) on 2011June 14 shows that the output value of biotechnology industry increased steadily in 20 10, which is the second profit year after the global biotechnology industry achieved the whole industry profit for the first time in 2009. By the end of 20 10, there were more than 4,700 biotechnology enterprises in the world (mainly distributed in the United States, Canada, Europe and Australia), among which 622 were listed biotechnology companies. The total income of listed biotech companies was $84.6 billion, R&D investment was $22.8 billion, and net profit was $4.7 billion, an increase of 30% over 2009. In 2009, the output value of China's bio-industry reached about 1.4 trillion yuan, including the output value of pharmaceutical industry 1038 1 billion yuan, bio-agriculture 1.20 billion yuan, bio-manufacturing industry 1.80 billion yuan, and bioenergy. In 20 10, the output value of bio-industry in China exceeded10.5 trillion yuan.
(d) Biotechnology will become a breakthrough point to solve major human problems.
2 1 century, the problems of health, food, energy and environment faced by the development of human society are becoming increasingly serious. Modern life science and biotechnology research provide scientific and feasible solutions to these major challenges. In agriculture, biotechnology is an important way to improve the level of agricultural science and technology, promote the upgrading of agricultural industrial structure and ensure national food security. Biological breeding technology will greatly increase the yield and enrich the types of agricultural products. In medical treatment, with the development of economy and the progress of society, the "4P" medicine, which is predictive, preventive, individualized and participatory, will replace the traditional diagnosis and treatment based on treatment. The development of population screening, histology and bioinformatics in Qualcomm will provide the possibility for preventive medicine and individualized treatment. Somatic cell reprogramming technology solves the difficult problems faced by bioethics. Regenerative medicine with stem cells and tissue engineering technology as the core shows great application prospects and is expected to become a new treatment model after drugs and surgery. Bio-based materials have brought great changes to the field of materials. Bio-manufacturing technology with synthetic cells and biocatalysts as the core and bio-fuel technology with biomass as the raw material will gradually reduce economic dependence on oil, greatly reduce carbon dioxide (CO2) emissions, improve environmental quality, realize sustainable economic development, and lead mankind into a low-carbon life. The progress of biotechnology and industrial development will bring great changes to our lifestyle and social and economic development.
(e) Biotechnology will become the supporting point of biosafety.
With the acceleration of globalization and the rapid development of biotechnology, the situation of biological security is becoming increasingly severe, and it has gradually become a basic problem of world security and development involving politics, military affairs, economy, science and technology, culture and society. Developed countries, represented by the United States, have invested heavily in the field of biosafety to consolidate and expand their dominant position, and the comprehensive strength of biosafety has developed rapidly. According to experts' estimation, the economic loss caused by only 1 1 species of agricultural alien invasive organisms in China exceeds 57.4 billion yuan every year. Since 2003, severe acute respiratory syndrome, highly pathogenic avian influenza and influenza A (H 1N 1) have been rampant, warning us to pay more attention to the safety problems caused by emerging infectious diseases. China is one of the countries with the richest biological resources in the world, and it is also an important target area for developed countries to plunder biological resources. It is estimated that the import and export ratio of biological genetic resources in China is about 1: 10, and the loss situation is quite serious. China's ability to defend against bioterrorism needs to be strengthened. Due to the destruction of natural forests, the habitat and distribution area of wild animals are shrinking day by day, and the biodiversity is sharply reduced due to man-made deforestation. 15-20% of the animal and plant species in China are threatened. It is urgent to protect biodiversity and ecosystem security in China. The key to solve the biosafety problem lies in accelerating the research and development of biotechnology such as medicine, agriculture and environment, and ensuring national interests and biosafety.
Second, the overall thinking and guiding principles
(A) the overall thinking
During the Twelfth Five-Year Plan period, China's biotechnology development must hold high the great banner of Socialism with Chinese characteristics, take Deng Xiaoping Theory and Theory of Three Represents as the guidance, thoroughly implement the Scientific Outlook on Development, fully implement the Outline, adhere to the guiding principles of independent innovation, focusing on leapfrogging, supporting development and leading the future, closely focus on the major strategic needs of China's economic and social development, seize the commanding heights of cutting-edge technologies, cultivate the growth points of strategic emerging industries, select the breakthrough points of independent innovation, and consolidate the support points of scientific development.
(2) Guiding principles
1. Overall deployment, step by step implementation. Keep up with the forefront of international biotechnology development, aim at the major strategic needs of the country, take into account the reality and medium-and long-term development according to the key points of major national science and technology plans, integrate resources covering various fields such as medicine, agriculture, manufacturing, energy and environmental protection, and integrate the forces of various departments and localities to make overall plans and implement them step by step. Reflect the relationship between basic research, applied research and industrialization.
2. Highlight innovation and support industries. Fully absorb the latest achievements of cutting-edge biotechnology, combine original innovation with integrated innovation, introduce, absorb, digest and re-innovate, strengthen collaborative innovation, form independent core technologies, cultivate original innovation achievements, and form sustainable development capabilities. Multi-disciplinary, multi-unit, covering key technologies and products in the upper, middle and lower reaches, transforming and upgrading the existing industrial structure, and supporting the development of strategic emerging industries.
3. Point-to-surface combination and leapfrog development. Focus on research and development of cutting-edge key technology points, major technology systems and major products represented by the new generation sequencing technology, build a major technology system driven by the industry, establish a national biotechnology incubator and integrated demonstration base, and integrate Industry-University-Research capital and other forces to promote the leap-forward development of the biotechnology industry.
Three. Development goals
During the "Twelfth Five-Year Plan" period, the goals of China's biotechnology development are: the independent innovation ability of biotechnology has been significantly improved, the overall level of biotechnology has entered the world advanced ranks, and some areas have reached the world leading level. The industries of biomedicine, bio-agriculture, bio-manufacturing, bio-energy and bio-environmental protection have risen rapidly, and the overall layout of bio-industry has basically taken shape, which has promoted bio-industry to become one of the pillar industries of the national economy and made China a powerful country in biotechnology and bio-industry. Among them, the total number of published SCI papers has reached the top three in the world; The total number of invention patent applications and authorizations has entered the top three in the world; There are more than 300,000 R&D personnel in biotechnology, and the total amount of biotechnology human resources ranks first in the world. The average annual growth rate of bio-industry remains above 15%.
Fourth, key tasks
Key tasks cover basic research, applied research and industrialization. It has been implemented through national science and technology major projects, national key basic research and development plan (973 plan), national high-tech research and development plan (863 plan) and national science and technology support plan. Among them, the basic research on major scientific issues in the development of life science and biotechnology is mainly carried out by the 973 program; The core frontier technologies and key technologies in biotechnology and industrial development are mainly supported by the 863 Program. The transformation, application and industrialization demonstration of biotechnology achievements are mainly supported by the national science and technology support plan; Major technical problems and integrated technology demonstrations involving global, cross-industry and cross-regional development of biotechnology are mainly supported by major national science and technology projects, and all sectors of society are mobilized through market mechanisms, and * * * cooperates with the promotion; The related innovation capacity building is jointly supported by the corresponding plans of the Ministry of Science and Technology and the Development and Reform Commission.
The implementation of the key tasks of this plan shall be organized and implemented in the corresponding national science and technology plans in an annual, step-by-step and planned manner, and implemented in accordance with the organization and implementation management mode of each plan, so as to make good connection and cooperation between science and technology plans. Establish and improve the inter-ministerial coordination mechanism related to the development of biotechnology and bio-industry, hold regular departmental coordination meetings, coordinate the national scientific, technological, economic and social development plans as a whole, integrate the funds and strength of various national scientific and technological plans, strengthen the connection and cooperation, allocate resources scientifically, reasonably and effectively, fully promote the research and development of biotechnology, industrialization and enterprise innovation capacity building, and form a strong synergy to promote the rapid development of biotechnology and industry in China.
(A) to strengthen forward-looking basic research
Facing the change of China's economic and social development mode and the challenge brought by the new round of scientific and technological revolution, we should choose key bottleneck problems, strengthen forward-looking basic research, continuously improve the level of basic research in China's biotechnology field and the ability to solve major scientific problems, promote the combination of basic research and technical science, and lead the future development of high and new technology.
Development priorities:
1, agricultural science
Focusing on major scientific issues such as agricultural animal and plant breeding, scientific breeding and cultivation, efficient utilization of resources, effective prevention and control of pests and diseases, and improvement of ecological environment, we will carry out research on efficient utilization of farmland resources with high yield, high quality, disease resistance and high efficiency, pest control, biosafety and agricultural product safety, and build a sustainable comprehensive system of agriculture, forestry, grass ecology and agriculture.
2. Population and Health Science
Combined with the frontier of life science development, around the pathogenesis of diseases and major scientific problems in their prevention and treatment, we will carry out basic research on the mechanism and prevention of chronic and complex diseases such as non-communicable diseases, aging and aging-related diseases, family planning and reproductive health, disaster medicine, infection and immunity; In view of the huge demand of infectious diseases, study the pathogenesis of major pathogens and important infectious diseases, create scientific problems of important vaccines, and create new technologies for diagnosis, treatment and early warning of important infectious diseases; Focusing on the traditional Chinese medicine with China characteristics, we will interpret the scientific connotation of the basic theory of traditional Chinese medicine, and innovate and develop basic research related to the basic theory of traditional Chinese medicine, the application of traditional Chinese medicine and prescriptions, and the dialectical demonstration of acupuncture and moxibustion.
3. Industrial Biological Sciences
Research on new functional artificial life devices and their integration, network analysis of genomics, principles and technologies of genome fine synthesis, new theories, new approaches and new methods for the synthesis of major bio-based products, etc.
(B) Breakthrough a number of core key technologies
Select core key technologies with China characteristics and advantages, concentrate superior resources, achieve key breakthroughs, strive to occupy a place in the international frontier science field of biology, and seize the commanding heights of a number of international biotechnology research and development.
Development priorities:
1, "omics" technology
Taking the development of a new generation of sequencing technology as a breakthrough, we will realize the leap-forward development of biotechnology in China, promote the rapid development of genomics technology, transcriptome technology, protein group technology, metabonomics technology, epigenetics technology, structural genomics technology, and develop quantitative biomedical data analysis and text mining technology in Qualcomm, quantitative sample analysis technology in Qualcomm, micro-sample extraction and amplification technology, massive data analysis technology, etc. Accelerate the application of genomics technology and bioinformatics technology in disease prevention and control, clinical diagnosis and treatment, biological manufacturing and variety creation.
2. Synthetic biotechnology
Develop Qualcomm-quantitative and low-cost DNA synthesis technology and efficient assembly technology of gene fragments, protein's structure and function analysis, directional design and synthesis technology, standardize the construction technology of biological components and functional modules, and establish the application technology of synthetic biology in drug precursors and intermediates, bioenergy and bio-based chemicals. And gradually explore the application of synthetic biology in the fields of medicine and energy.
3, biological information technology
Breakthrough the key technologies such as calculation, design, assembly and application of biological regulatory elements, develop individual genomes, population genomes, individualized information search engines and various new biological data analysis technologies, and study disease risk analysis, disease diagnosis and treatment models and systems based on individual omics data; Research on data mining and analysis technology related to agricultural biological stress: establish a national technical platform for data collection, management and sharing in the fields of life science and medical technology.
4. Stem cells and regenerative medicine technology
To study the differentiation and development of embryonic stem cells, adult stem cells and induced pluripotent stem cells (iPS cells) and the mechanism of their interaction with the microenvironment in vivo, cell reprogramming, genetic differentiation and induced differentiation of stem cells, isolation, identification, amplification and identification of stem cells, immune rejection, safe implantation of stem cells and accurate observation and tracing in vivo, three-dimensional construction of complex organs, and preservation technology of tissue engineering medical products.
5, gene therapy and cell therapy technology
In view of serious diseases such as malignant tumors, cardiovascular and cerebrovascular diseases, hereditary diseases and autoimmune diseases, a number of prospective studies on key technologies of biotherapy such as targeted gene therapy, cell therapy and immunotherapy are carried out, and breakthroughs in key technologies drive the research and development of key products and accelerate the application of biotherapy technologies in clinical treatment.
6, molecular typing and individualized diagnosis and treatment technology
Molecular typing and staging of major diseases and common diseases and key technologies for early diagnosis of diseases; Establish standardized, standardized and digital clinical data, specimen database and information system; Genome-wide association studies technology for studying major diseases, discovery, confirmation and clinical evaluation of biomarkers for molecular typing of major diseases, and individualized clinical diagnosis and treatment plan for major diseases.
7, biochip and biological imaging technology
Research and development of gene chips, protein chips and chip lab products with independent intellectual property rights and market prospects for clinical testing and health and epidemic prevention. Study the structure, three-dimensional morphology and fast-changing super-resolution imaging of biomolecules, and large-scale and cross-level high-resolution biological imaging; Study on fast, nondestructive and parallel Qualcomm imaging monitoring with single-molecule resolution/multi-molecule network regulation, three-dimensional nondestructive imaging monitoring in vivo at the whole level of cells, model animals and human body, and three-dimensional nondestructive imaging monitoring of high-resolution structure and function of nervous system; In this paper, the integrated modeling method based on multi-level and multi-parameter image information is studied by combining the image information monitoring and characterization of clinical major diseases diagnosis and treatment.
8, biological process engineering technology
Research and development of on-line detection technology and optimization control technology for macro-metabolic information and cell growth environment information of biological processes; Separation, extraction and refining technology of biological macromolecules and biological macromolecules; Coupling technology of fermentation process and separation; Design, scale-up and manufacturing technology of new efficient animal and plant cell bioreactor and photobioreactor.
9, biocatalysis engineering technology
Carry out research on key technologies such as directional transformation, high-efficiency expression, immobilization, coenzyme regeneration, multi-enzyme coupling, enzyme-chemical coupling, enzyme-fermentation coupling, asymmetric and enantioselective biotransformation technology, optimization and amplification technology of non-aqueous biocatalysis reaction process, establish biocatalysis engineering technology with independent intellectual property rights, low cost and industrialized production, and improve the research and development and application level of industrial enzymes in China.
10, drug target discovery and drug molecular design technology
Research on network analysis technology of drug targets based on system biology, conformational simulation technology of protein function and biological activity of targets, Qualcomm screening model based on new functional genes and their signal pathways, drug design technology based on structure and aiming at multiple targets, computer-aided combinatorial compound library design, synthesis and screening, drug lead compound design method, virtual design technology of compound drug evaluation, network pharmacology design technology, drug metabolism engineering simulation and other key technologies.
1 1, design technology of animal and plant varieties
Take main plants (rice, wheat, corn, soybean, cotton, rape, vegetables, forest and grass, etc.). ) and animals (pigs, cows, sheep, chickens, etc. ) as the research object, the molecular composition analysis of important animal and plant variety traits and polygene polymerization of excellent traits were studied emphatically; Information system, variety molecular design engineering, technical system and verification of animal and plant variety molecular design.
12, Key Technologies of Biosafety
Research on key technologies of biosafety monitoring and early warning and research and development of emergency drugs and equipment for public health emergencies; Study the cross-species transmission mechanism of pathogens and establish the traceability technology of pathogens related to biological threats; Carry out research on key technologies of biological invasion protection.
(three) research and development of a number of major products and technical systems.
Focusing on the urgent need to change the mode of economic development and develop strategic emerging industries in China, we should strengthen the integrated innovation of biotechnology, strive to break through a number of key technologies, develop major products with independent intellectual property rights and market competitiveness, and focus on promoting the development of biomedicine, bio-agriculture, bio-manufacturing, bio-energy and bio-environmental protection industries, so as to realize the strategic transformation of China's biotechnology research and development from technology accumulation to industrial development.
Development priorities:
1, biomedical technology and products
In order to meet the people's basic drug demand and cultivate and develop the pharmaceutical industry, we will break through a number of key technologies and production processes for drug creation, develop innovative drugs, transform drug varieties, improve the technological platform for new drug creation and modernization of traditional Chinese medicine, build a number of strategic alliances for technological innovation in the pharmaceutical industry, and basically form a national drug innovation system with China characteristics.
Focusing on major infectious diseases such as AIDS, viral hepatitis and tuberculosis, we will break through key technologies such as clinical diagnosis, prediction and early warning, vaccine research and development and clinical treatment, and develop new diagnostic reagents and vaccines to effectively reduce the new infection rate and mortality rate of AIDS, viral hepatitis and tuberculosis.
Establish a new technology for large-scale and rapid production of vaccines and antibodies, a systematic technical system for evaluating the effectiveness and quality of vaccines, and the construction and optimization technology of humanized antibody; Transform traditional vaccines to increase efficiency, and develop new vaccines and antibody drugs for emerging and recurrent major infectious diseases and multiple infectious diseases; Develop therapeutic vaccines and antibody drugs for major non-communicable diseases such as malignant tumors, cardiovascular and cerebrovascular diseases, metabolic diseases and autoimmune diseases.
Break through a number of key technologies of in vitro diagnostic instruments and reagents, develop a number of innovative products with independent intellectual property rights, achieve key breakthroughs in high-end products such as integrated chemiluminescence immunoassay systems, accelerate the adjustment and optimization of in vitro diagnostic industry structure, and greatly enhance the market competitiveness of China's in vitro diagnostic industry.
We will break through a number of advanced high-end biomedical materials, carry out research and development of a number of high-value alternative products that mainly rely on imports, create a number of large-scale biomedical materials, and break through key technologies such as personalized design of biomedical materials, surface modification of biomedical materials, biomechanics, durability and safety testing of biomedical materials.
2. Bio-agricultural technology and products
Focus on the production of major crops and livestock, and break through key technologies such as gene cloning and functional verification, large-scale transgenic, and biosafety. , improve the cultivation and safety evaluation system of genetically modified organisms, obtain a number of functional genes with important application value and independent intellectual property rights, cultivate a number of major genetically modified new varieties with insect resistance, stress resistance, high quality, high yield and high efficiency, realize the industrialization of new varieties such as genetically modified cotton and high-quality corn, improve the overall level of biological breeding in China, enhance the independent innovation ability of agricultural science and technology, and promote agricultural efficiency.
In order to achieve large-scale development, accelerate the research and development and industrialization of green agricultural biological products and forest pest control technologies; Carry out demonstration and promotion of the application of green agricultural products such as biological pesticides, biological veterinary drugs, animal vaccines, biological fertilizers and green plant growth regulators, and promote the research and development and industrialization of fully degradable agricultural films; Research and development of biological pesticides, biological fertilizers, new animal vaccines and diagnostic reagents, biotechnology drugs, veterinary drugs and biological feed additives.
In view of special biological resources, we will focus on the engineering research of important rare medicinal fungi resources such as Cordyceps sinensis and Ganoderma lucidum, and develop high value-added products; Explore and screen biological resources that grow in special environment and have important application value, carry out research on artificial cultivation technology, establish seedling breeding base and develop deep-processed products.
Research and development of new varieties of marine fishery breeding and key technologies of standardized, large-scale and ecological healthy aquaculture, development of monitoring and forecasting of major aquaculture diseases and immune control technologies, and establishment of aquatic product quality inspection system.
3, biological manufacturing technology and products
Focus on key technologies such as the construction and optimization of biosynthetic pathway of chemical products, comprehensive utilization and biorefinery of raw materials, industrial biocatalysis and transformation, and biochemical combination synthesis, and break through the industrialization bottleneck of bio-manufacturing of major chemical products such as bio-based platform compounds, chiral chemical intermediates, and bio-based materials. Form a platform technology system for the manufacture of organic acids, chemical alcohols, bio-based materials and other products, and form an innovative bio-manufacturing route for the production of high value-added chiral intermediates such as chiral alcohols, chiral acids and steroids.
Research and develop the application of biotechnology in textile, papermaking, tanning and other industries, develop new technologies and equipment such as bio-textile, bio-degumming, bio-tanning and bio-papermaking, promote the application of biotechnology in textile, papermaking, leather and other enterprises, and promote cleaner production in the industry.
Traditional brewing products such as wine, soy sauce and vinegar are selected, and modern biotechnology and engineering technology are applied to improve strains, optimize brewing technology, improve product quality, reduce resource consumption, reduce environmental pollution and improve the overall competitiveness of the industry.
4, bioenergy technology and products
Research and development of key technologies and special equipment in the manufacturing process of bio-energy products such as non-grain bio-ethanol, bio-diesel, biogas, bio-hydrogen production, and the establishment of large-scale production technology demonstration of bio-energy products with industrial and municipal solid waste as raw materials.
Develop key technologies of microalgae biological carbon fixation, establish an industrial demonstration system with annual carbon fixation exceeding 1 10,000 tons, take the lead in realizing the industrialization of microalgae carbon fixation in the world, develop a series of microalgae products with high added value, provide technical, economic and environmental evaluation indicators for microalgae large-scale carbon fixation and microalgae energy development, and provide a demonstration for the large-scale popularization and application of microalgae biological carbon fixation technology.
5, biological environmental protection technology and products
Vigorously develop new technologies, new processes and new equipment for environmental protection; Focus on the development of high-performance biological products such as flocculants and coagulants for water treatment, the development of biological purification technology for waste gas and wastewater, and the development of new aerobic, anaerobic and compound high-efficiency reactors and new processes for efficient biological nitrogen and phosphorus removal; We will develop new biological varieties for pollutant degradation, develop biodegradation technologies for organic pollutants in oil refining, pharmaceutical and chemical industries, and promote biodegradation and remediation of pollutants such as oil, heavy metals and pesticides.
For coal, industrial waste gas and flue gas, research on microbial desulfurization technology will be carried out, focusing on the breeding technology of high-efficiency functional bacteria, the control technology of microbial sulfur metabolism pathway and the composite microbial desulfurization technology, and the composite technology of multi-flora, single/multiphase reactor and biochemical/physicochemical method will be carried out to promote the industrial application of microbial desulfurization technology.
(4) Strengthening the capacity building of biotechnology innovation.
According to the development needs of biotechnology itself, we will systematically strengthen the capacity building of biotechnology innovation, optimize the allocation of scientific and technological resources in the fields of life science and biotechnology research, and build state key laboratories, national engineering technology research centers, research platforms and industrialization demonstration bases with reasonable layout, scientific efficiency and world-class level, so as to promote the integrated development of biotechnology resources and provide effective support for biotechnology research and industrialization of achievements.