Why is ketogenic diet at risk of vascular injury?

The researchers took nine healthy young men as subjects, and asked them to drink a drink containing 75 grams of glucose after seven days of ketogenic diet. Their ketogenic diet structure is 70% fat, 10% carbohydrate and 20% protein, which is in line with the current popular ketogenic diet.

The results showed that some biomarkers appeared in these people, suggesting that the blood vessel wall was damaged. The researchers believe that the main reason for this damage is that the short-term ketogenic diet destroys the glucose homeostasis in the body. After the recovery of carbohydrate intake, the rapid increase of blood sugar triggered a metabolic reaction, leading to the shedding of vascular cells.

Jonathan Littell, correspondent of the study and associate professor of the University of British Columbia, Okana Root, said that once blood sugar surges after using ketogenic diet, blood vessels will be adversely affected.

The researchers said that because the participants in this study are all men and the number is small, they need to do more research in the future to verify these findings.

Some people think that ketogenic diet can make the body enter a "ketosis" state, and body fat replaces glucose as the energy source. But some experts believe that sticking to this diet for a long time has health risks.

Short-term use of ketogenic diet has a certain health care effect on the body, and can be used for people who need to lose weight quickly because of other physical and medical conditions. Tentative indications of ketogenic diet: simple obesity, age 18 years old or above, normal liver and kidney function, body mass index ≥28kg/㎡. Because ketogenic diet is a kind of therapy that uses fat instead of glucose as energy source, all diseases with fatty acid transport and oxidation disorders are contraindications; Ketogenic diet is also not suitable for patients with a history of pancreatitis, renal failure, active gallbladder disease, hepatic and renal insufficiency, hyperlipidemia, severe cardiorespiratory diseases, pregnancy and lactation. Please consult a professional doctor for details.