In the west, edward jenner, a British village doctor, found a less dangerous vaccination method. He successfully injected an 8-year-old boy with vaccinia.
Extended data:
The average incubation period after smallpox virus infection is about 12 days (7- 17 days). The initial symptoms after infection include high fever, fatigue, headache and back pain. Typical acne rash will appear after 2-3 days, which is obviously distributed on the face, arms and legs.
At the beginning of the rash, there will be a red block area accompanied by a rash. After a few days, the lesion began to fester, and it didn't start to scab until the second week. In the next 3-4 weeks, it will develop into scabies and then slowly fall off.
During this incubation period, some patients have nightmares that last for three or four days. Patients with fair skin often have scattered dark red spots on their faces, sometimes all over the body. At the end of the incubation period, the patient's high fever decreased and he felt that his condition was temporarily improved. It was at this time that smallpox virus began to produce its signature rash on patients to announce its existence.
References:
Baidu encyclopedia-smallpox virus