Kidney is not good, when is it most obvious?

Patients with poor kidneys have no obvious symptoms in the early stage, such as fatigue, fatigue, waist and knee pain, loss of appetite and so on. In the early stage of chronic renal failure, symptoms such as nausea, vomiting and loss of appetite will appear in the morning. With the increase of creatinine, uremia will enter the end stage, and symptoms of various systems will appear. Symptoms include nausea, vomiting, even gastrointestinal bleeding, chest tightness, shortness of breath, dyspnea and other heart failure manifestations, skin itching, renal osteopathy, such as bone pain, fracture and osteoporosis, nervous system symptoms and uremic encephalopathy, such as inattention, memory loss, hallucinations, confusion, delirium, lethargy, even coma and lethargy, and peripheral nervous system symptoms. Women will have menstrual disorders and amenorrhea, and male patients will have impotence and premature ejaculation. At this time, renal replacement therapy, such as hemodialysis or peritoneal dialysis, should be performed.