COVID-19 Inactivation Mask for Health Box adopts five-layer structure, with two layers of copper oxide non-woven fabrics inside and outside, two layers of 99-grade meltblown fabrics and one layer of non-woven fabrics in the middle. The filtration efficiency of particles and bacteria can reach 99.9%. Moreover, using the antibacterial properties of copper ions, more than 200 kinds of viruses, bacteria and even mites can be inactivated through direct physical contact, effectively avoiding the secondary spread of viruses; Tested by P3 State Key Laboratory of Emerging Infectious Diseases, the inactivation rate of COVID-19 is as high as 99.7%, and the copper ion precipitation rate is one thousandth of the safe value, which is safe and non-irritating, and can be reused for 60 times.