Can flora transplantation treat diabetes?

The main mechanism of fecal transplantation may be the ecological occupation of beneficial bacteria in feces, anti-colonization, biological hypoxia, immune regulation, lowering pH value of intestinal cavity and nutrition of bacterial metabolites.

The most important thing in the transplanted feces is hundreds of millions of microorganisms that inhabit the intestines all the year round. Together with biological components such as intestinal epithelial cells, food-borne abiotic components (undigested food) and secretions of stomach, intestine, pancreas and liver (such as hormones, enzymes, mucus and bile salts, etc.). ), they form intestinal microecosystem. The significance of fecal transplantation lies in rebuilding the normal intestinal microecological structure.

Extended data

In recent years, more and more scientific research results show that the composition of intestinal flora is closely related to metabolic diseases. Zhao Liping Laboratory of Shanghai Jiaotong University introduced a strain of intestinal bacteria from obese patients into infertile mice, causing severe obesity and insulin resistance, which provided the most direct experimental evidence for the participation of intestinal flora in the occurrence and development of metabolic diseases such as obesity and diabetes.

They also improved the intestinal flora structure of patients by adjusting their diet, thus significantly improving the symptoms of obesity and chronic diseases. These studies will help to clarify the mechanism of obesity and diabetes caused by the interaction between intestinal flora and diet, and it is expected to develop new methods to prevent obesity and diabetes with intestinal flora as the target.

Baidu encyclopedia-fecal transplantation

People's Daily Online-China has taken new measures to prevent and treat obesity and diabetes by targeting intestinal flora.